SERP1 Antibody

Code CSB-PA021051GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SERP1
Alternative Names
D3Ucla1 antibody; Ramp4 antibody; Ribosome associated membrane protein 4 antibody; Ribosome attached membrane protein 4 antibody; Ribosome-attached membrane protein 4 antibody; Serp1 antibody; SERP1_HUMAN antibody; Stress associated endoplasmic reticulum protein 1 antibody; Stress-associated endoplasmic reticulum protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SERP1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins.
Gene References into Functions
  1. Study demonstrated that SERP1 expression level was significantly upregulated in human pancreatic ductal adenocarcinoma (PDAC) tissues which positively associated with advanced clinical stage and shorter survival time (OS and DFS). Downregulated SERP1 expression promoted PDAC cell apoptosis and inhibited NF-kappaB activation probably by upregulating SRPRB expression. PMID: 28902358
  2. expression of SFRP1 mRNA and protein correlates with the Gleason score, survival rate and response for endocrine therapy of prostate cancer. PMID: 25719802
  3. SFRP1 DNA methylation, accumulates with age in normal-appearing kidney tissues and is associated with increased renal cancer risk. PMID: 22419128
  4. SERP1 is a novel cochaperone and regulator of ENaC expression. PMID: 22526458
Subcellular Location
Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Protein Families
RAMP4 family
Database Links

HGNC: 10759

OMIM: 617674

KEGG: hsa:27230

STRING: 9606.ENSP00000239944

UniGene: Hs.518326

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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