SERPINB6 Antibody

Datasheet

Code	CSB-PA198452
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA198452(SERPINB6 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details
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Target Background

Product Details

Uniprot No.

P35237

Target Names

SERPINB6

Alternative Names

CAP antibody; Cytoplasmic antiproteinase antibody; Peptidase inhibitor 6 antibody; PI-6 antibody; PI6 antibody; Placental thrombin inhibitor antibody; Protease inhibitor 6 (placental thrombin inhibitor) antibody; PTI antibody; Serpin B6 antibody; SERPINB6 antibody; SPB6_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Fusion protein of Human SERPINB6

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.

Gene References into Functions

A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss. PMID: 20451170
In mast cells, SERPINB6 serves to regulate the activity of endogenous beta-tryptase in the cytoplasm. PMID: 14670919
Expressed in developing gonads and in both somatic and germ cells of adult gonads. PMID: 16175637
Protects the intracellular compartment of keratinocytes from ectopic kallikrein-8. PMID: 17761692
the discovery overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer. PMID: 19425502

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Involvement in disease

Deafness, autosomal recessive, 91 (DFNB91)

Subcellular Location

Cytoplasm.

Protein Families

Serpin family, Ov-serpin subfamily

Tissue Specificity

Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissu

Database Links

HGNC: 8950

OMIM: 173321

KEGG: hsa:5269

STRING: 9606.ENSP00000338358

UniGene: Hs.519523

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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