SGCG Antibody

Code CSB-PA021186GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. Q13326
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Human SGCG
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IHC
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein);SGCG;A4;DAGA4;DMDA;DMDA1;LGMD2C;MAM;MGC130048;SCARMD2;SCG3;TYPE ;
Immunogen Species Homo sapiens (Human)
Target Names SGCG
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C).
HGNC 10809
RGD 1359577
MGI 1346524
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Function Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Involvement in disease Limb-girdle muscular dystrophy 2C (LGMD2C)
Subcellular Location Cell membrane, sarcolemma, Single-pass type II membrane protein, Cytoplasm, cytoskeleton
Protein Families Sarcoglycan beta/delta/gamma/zeta family
Tissue Specificity Expressed in skeletal and heart muscle.
Database Links

HGNC: 10809

OMIM: 253700

KEGG: hsa:6445

STRING: 9606.ENSP00000218867

UniGene: Hs.37167

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