SH2D4A Antibody

Code CSB-PA050002
Size US$100
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Product Details

Uniprot No.
Target Names
SH2D4A
Alternative Names
FLJ20967 antibody; PPP1R38 antibody; Protein phosphatase 1 regulatory subunit 38 antibody; Protein SH antibody; Protein SH(2)A antibody; Protein SH2A antibody; SH2 domain containing 4A antibody; SH2 domain containing protein 4A antibody; SH2 domain-containing protein 4A antibody; SH24A_HUMAN antibody; SH2A antibody; Sh2d4a antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human SH2D4A.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
Gene References into Functions
  1. The chromosome 8p tumor suppressor genes SORBS3 and SH2D4A are physically and functionally linked and provide a molecular mechanism of inhibiting STAT3-mediated IL-6 signaling in hepatocellular carcinoma cells. PMID: 27311882
  2. New evidence for SH2D4A involvement in hepatocellular carcinoma pathogenesis demonstrating for the first time its deregulation in cirrhotic nodules. PMID: 24315626
  3. SH2D4A is dispensable for TCR signal transduction in T cells PMID: 18641339
  4. SH2D4A inhibited cell proliferation by suppression of the ERalpha/PLC-gamma/PKC signaling pathway. PMID: 19712589
Subcellular Location
Cytoplasm.
Tissue Specificity
Ubiquitously expressed. Aberrantly expressed in some cancers.
Database Links

HGNC: 26102

OMIM: 614968

KEGG: hsa:63898

STRING: 9606.ENSP00000265807

UniGene: Hs.303208

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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