SH2D4A Antibody

Code CSB-PA021214GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SH2D4A
Alternative Names
FLJ20967 antibody; PPP1R38 antibody; Protein phosphatase 1 regulatory subunit 38 antibody; Protein SH antibody; Protein SH(2)A antibody; Protein SH2A antibody; SH2 domain containing 4A antibody; SH2 domain containing protein 4A antibody; SH2 domain-containing protein 4A antibody; SH24A_HUMAN antibody; SH2A antibody; Sh2d4a antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human SH2D4A
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
Gene References into Functions
  1. The chromosome 8p tumor suppressor genes SORBS3 and SH2D4A are physically and functionally linked and provide a molecular mechanism of inhibiting STAT3-mediated IL-6 signaling in hepatocellular carcinoma cells. PMID: 27311882
  2. New evidence for SH2D4A involvement in hepatocellular carcinoma pathogenesis demonstrating for the first time its deregulation in cirrhotic nodules. PMID: 24315626
  3. SH2D4A is dispensable for TCR signal transduction in T cells PMID: 18641339
  4. SH2D4A inhibited cell proliferation by suppression of the ERalpha/PLC-gamma/PKC signaling pathway. PMID: 19712589
Subcellular Location
Cytoplasm.
Tissue Specificity
Ubiquitously expressed. Aberrantly expressed in some cancers.
Database Links

HGNC: 26102

OMIM: 614968

KEGG: hsa:63898

STRING: 9606.ENSP00000265807

UniGene: Hs.303208

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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