SH3D19 Antibody, FITC conjugated

Code CSB-PA711356LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SH3D19 Polyclonal antibody
Uniprot No.
Target Names
SH3D19
Alternative Names
SH3D19 antibody; SH3 domain-containing protein 19 antibody; ADAM-binding protein Eve-1 antibody; EEN-binding protein antibody; EBP antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human SH3 domain-containing protein 19 protein (468-767AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization.
Gene References into Functions
  1. identified and characterized EBP, a novel EEN binding protein that interacts with the SH3 domain of EEN; normally expressed in cytoplasm but recruited to the nucleus by MLL-EEN [EBP] PMID: 14551139
  2. yeast two-hybrid screening using the cytoplasmic domain of ADAM12 as bait identified a protein designated Eve-1. Eve-1 plays a role in positively regulating the activity of ADAMs in the signaling of EGFR-ligand shedding. PMID: 15280379
  3. occurrence of an unusual TG 3' splice site in intron 6 PMID: 17672918
Subcellular Location
Cytoplasm. Nucleus. Note=Is recruited to the nucleus by the KMT2A/MLL1-EEN fusion protein.
Tissue Specificity
Widely expressed with highest levels in heart, skeletal muscle, kidney, liver, placenta, small intestine and lung. Expressed at low levels in colon, thymus, spleen and leukocytes.
Database Links

HGNC: 30418

OMIM: 608674

KEGG: hsa:152503

STRING: 9606.ENSP00000302913

UniGene: Hs.744983

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