SH3GL2 Antibody

Code CSB-PA021231GA01HU
Size US$685
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Product Details

Uniprot No. Q99962
Target Names SH3GL2
Alternative Names bA335L15.1 (SH3 domain GRB2 like 2) antibody; CNSA2 antibody; EEN B1 antibody; EEN-B1 antibody; Endophilin 1 antibody; Endophilin A1 antibody; Endophilin A1 BAR domain antibody; Endophilin-1 antibody; Endophilin-A1 antibody; FLJ20276 antibody; FLJ25015 antibody; OTTHUMP00000021084 antibody; SH3 domain containing GRB2 like protein 2 antibody; SH3 domain GRB2 like 2 antibody; SH3 domain protein 2A antibody; SH3 domain-containing GRB2-like protein 2 antibody; SH3D2A antibody; SH3G2_HUMAN antibody; Sh3gl2 antibody; Sh3p4 antibody; SH3PA antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human SH3GL2
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Gene References into Functions
  1. The results suggest that SH3GL2 suppresses migration and invasion behaviors of glioma cells through negatively regulating STAT3/MMP2 signaling. PMID: 28470949
  2. Alix acts in concert with endophilin A to promote clathrin-independent endocytosis of cholera toxin and to regulate cell migration. PMID: 27244115
  3. This study identified a new mitochondria reprogramming pathway influencing breast cancer progression through SH3GL2 and MFN2. These proteins were frequently lost in breast cancer, which was traceable in the circulating exosomes. PMID: 26888829
  4. Endophilin-1 was a direct and functional downstream target of miR-107. PMID: 27038654
  5. Methylation status of SH3GL2 gene was associated with the TNM staging and HPV infection status of vulvar squamous cell carcinoma. PMID: 26823912
  6. Endophilin-1 positively regulated blood-brain barrier permeability via the EGFR-JNK signaling pathway in hCMEC/D3 cells, which would provide an experimental basis for further research on endophilin-1 mediated the opening of blood-brain barrier . PMID: 25721793
  7. these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap PMID: 25771685
  8. Data indicate that the presence of the susceptible G allele in SNP rs1049430 is associated with the inactivation of SH3-domain GRB2-like 2 protein (SH3GL2) and could be used as a prognostic marker of head and neck squamous cell carcinoma (HNSCC). PMID: 25728707
  9. study described that endophilin-1 is expressed in hCMEC/D3 cells where it regulates the permeability of blood-brain barrier by altering the expression of ZO-1 and occludin via the EGFR-ERK1/2 pathway PMID: 24854121
  10. miR-330 negatively regulated the expression of SH3GL2 in GSCs, which promoted the oncogenic progression of GSCs through activating ERK and PI3K/AKT signaling pathways. PMID: 24736727
  11. these findings identify loss of Sh3gl2 as a frequent event in Urothelial carcinoma (UC) development that promotes disease progression. PMID: 23814487
  12. this study suggests a novel mechanism in which Lpd mediates EGFR endocytosis via Mena downstream of endophilin. PMID: 24076656
  13. Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes. PMID: 23675485
  14. Data suggest that expression of endothelin-1 and vWF (von Willebrand factor) is up-regulated and eNOS (endothelial nitric oxide synthase) activity is increased in radial artery in diabetic patients with coronary artery disease. PMID: 22972845
  15. Our results indicate that SH3GL2 is frequently deleted in NSCLC and regulates cellular growth and invasion by modulating EGFR function. PMID: 22968441
  16. SH3GL2 gene was identified as the target of miR-330. miRNA-330 plays an oncogenic role in human glioblastoma by regulating SH3GL2 gene and might be a new therapeutic target of human glioblastoma. PMID: 23029364
  17. simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1, co-regulated by Cbl-CIN85 and Endophilin A1 PMID: 21829671
  18. Alterations of SH3GL2 and CDKN2A loci have a synergistic role in the development of early-onset breast cancer. PMID: 18239974

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Subcellular Location Cytoplasm, Membrane, Peripheral membrane protein, Early endosome
Protein Families Endophilin family
Tissue Specificity Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
Database Links

HGNC: 10831

OMIM: 604465

KEGG: hsa:6456

STRING: 9606.ENSP00000369981

UniGene: Hs.743740

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