SHANK1 Antibody

Code CSB-PA021247GA01HU
Size US$685
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Product Details

Uniprot No. Q9Y566
Target Names SHANK1
Alternative Names GKAP/SAPAP interacting protein antibody; OTTHUMP00000174437 antibody; SH3 and multiple ankyrin repeat domains 1 antibody; SH3 and multiple ankyrin repeat domains protein 1 antibody; SH3/ankyrin domain gene 1 antibody; SHAN1_HUMAN antibody; SHANK 1 antibody; Shank1 antibody; Shank1a antibody; Somatostatin receptor interacting protein antibody; Somatostatin receptor-interacting protein antibody; SPANK 1 antibody; SPANK1 antibody; SSTR interacting protein antibody; SSTR-interacting protein antibody; SSTRIP antibody; Synamon antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human SHANK1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer 0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
Gene References into Functions
  1. Authors summarize and discuss behavioral and neuronal findings obtained in the Shank1 knockout mouse model for Autism spectrum disorder (ASD); identify open research questions by comparing such findings with the symptoms present in humans diagnosed with ASD and carrying SHANK1 deletions; conclude by discussing the implications of the behavioral and neuronal phenotypes displayed by the Shank1 knockout mouse model. PMID: 28963042
  2. SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane. PMID: 28263956
  3. Data show that the Shank1 protein mRNA 3' UTR adopts two very stable intramolecular G-quadruplexes which are bound specifically and with high affinity by X mental retardation protein (FMRP). PMID: 25692235
  4. a non-canonical initiation site is required for efficient translation of the dendritically localized Shank1 mRNA PMID: 24533096
  5. The results of this study suggested a role of SHANK1 in working memory deficits in schizophrenia. PMID: 21901269
  6. A hemizygous SHANK1 deletion segregates in a four-generation family in which male carriers--but not female carriers--have autism spectrum disorder with higher functioning. PMID: 22503632
  7. Results show that dendritic targeting of shank1 mRNA granules involves KIF5C and the KIF5-associated RNA-binding protein staufen1. PMID: 19416473

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Subcellular Location Cytoplasm, Cell junction, synapse, postsynaptic cell membrane, postsynaptic density, Cell junction, synapse
Protein Families SHANK family
Tissue Specificity Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.
Database Links

HGNC: 15474

OMIM: 604999

KEGG: hsa:50944

STRING: 9606.ENSP00000293441

UniGene: Hs.274255

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