SHPK Antibody

Code CSB-PA008437
Size US$100
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  • Western Blot analysis of Jurkat cells using CARKL Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
SHPK
Alternative Names
Carbohydrate kinase like antibody; Carbohydrate kinase like protein antibody; Carbohydrate kinase-like protein antibody; CARKL antibody; Sedoheptulokinase antibody; SHK antibody; Shpk antibody; SHPK_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the N-terminal region of Human CARKL.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a modulator of macrophage activation through control of glucose metabolism.
Gene References into Functions
  1. CARKL-dependent metabolic reprogramming is required for proper M1- and M2-like macrophage polarization PMID: 22682222
  2. the CARKL-encoded protein, sedoheptulokinase (SHK), is responsible for the reaction: sedoheptulose + ATP --> sedoheptulose-7-phosphate + ADP, and deletion of CARKL causes urinary accumulation of sedoheptulose and erythritol PMID: 18186520
Involvement in disease
Sedoheptulokinase deficiency (SHPKD)
Subcellular Location
Cytoplasm.
Protein Families
FGGY kinase family
Tissue Specificity
Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain.
Database Links

HGNC: 1492

OMIM: 605060

KEGG: hsa:23729

STRING: 9606.ENSP00000225519

UniGene: Hs.579217

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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