Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC18A1 Polyclonal antibody

Uniprot No.

P54219

Target Names

SLC18A1

Alternative Names

4832416I10Rik antibody; Adrenal chromaffin granule amine transporter, CGAT antibody; CGAT antibody; Chromaffin granule amine transporter antibody; MGC28683 antibody; MGC37299 antibody; SLC18A1 antibody; Solute carrier family 18 (vesicular monoamine), member 1 antibody; Solute carrier family 18 member 1 antibody; VAT 1 antibody; VAT1 antibody; Vesicular amine transporter 1 antibody; VMAT 1 antibody; VMAT1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Chromaffin granule amine transporter protein (66-120AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.

Gene References into Functions

SLC18A1 might complement other biomarkers currently under study in relation to programmed cell death protein 1/programmed cell death protein ligand 1 inhibition PMID: 30194079
Polymorphisms within the SLC18A gene are associated with asthenozoospermia through sperm count and motility. PMID: 29602729
Vmat1 polymorphisms are not associated with suicidal behavior. PMID: 29536333
results contribute to the evidence indicating an association between the VMAT1 gene and structural brain alterations in depression. PMID: 28408293
VMAT1 rs1390938/Thr136Ile is associated with mood, personality, and alcohol use in the general population. Subjects homozygous for the "hyperfunction" allele (AA; Ile/Ile) appear to be more resilient to these disorders. PMID: 26861143
The germline deletions at SLC18A1 contributed to the development of CRC. PMID: 28968818
rs2270641 SNP was associated with ASD risk only in over-dominant model. AA genotype of the rs1390938 was protective against ASD under dominant and recessive models. PMID: 28476685
Genetic variants in VMAT1 contribute to the severity of alcohol withdrawal in patients of European descent. PMID: 26876819
VMAT1 and VMAT2 are expressed in the majority of neuroblastomas PMID: 26338179
SLC18A1 gene polymorphisms are associated with the risk of paranoid schizophrenia in Russians and Tatars. PMID: 25842846
The data of this study showed that VMAT1 polymorphisms influence monoamine signaling, the functional response of emotional brain circuits and risk for psychopathology. PMID: 23337945
Deletion of amino acids 307-338 in hVMAT1 isoform-b abolishes transport activity, and a 136-Thr partially reduces activity of isoform-a. PMID: 23090274
we found a significant down-regulation of the gene coding for the vesicular monoamine transporter (VMAT1)in enteroendocrine cells infected with Chlamydia trachomatis PMID: 21883697
Human bronchial arterial smooth muscle cells express OCT-1 and extraneuronal monoamine transporter(EMT). EMT is the predominant plasma membrane transporter for norepinephrine uptake. PMID: 12807698
Greater expression of VMAT 1 in von Hippel-Lindau syndrome than multiple endocrine neoplasia type 2. Expression of VMAT 2 did not differ significantly. PMID: 16189177
VMAT1Delta15 is not localized in large, dense core vesicles as the native form but in the endoplasmic reticulum. While VMAT1 can take up serotonin, VMAT1Delta15 cannot, indicating different functions for the two forms of VMAT1. PMID: 16326835
Expression analysis confirmed that VMAT1 is expressed in human brain at the mRNA and protein level. Results suggest that variations in the VMAT1 gene may confer susceptibility to Bipolar Disorder in patients of European descent. PMID: 16936705
Our findings support the hypothesis that anxiety-related personality traits are associated with variation in the VMAT1/SLC18A1 gene. PMID: 18249496
Polymorphism in VMAT1 gene on chromosome 8p is associated with schizophrenia. PMID: 18451639

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Subcellular Location

[Isoform 1]: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

Major facilitator superfamily, Vesicular transporter family

Tissue Specificity

Highly expressed in chromaffin cells of the adrenal medulla (at protein level). Detected in peripheral sympathetic ganglia (at protein level). Found in some paracrine cells in stomach and duodenum (at protein level).

Database Links

HGNC: 10934

OMIM: 193002

KEGG: hsa:6570

STRING: 9606.ENSP00000276373

UniGene: Hs.158322