SLC18A1 Antibody, HRP conjugated

1. SLC18A1 might complement other biomarkers currently under study in relation to programmed cell death protein 1/programmed cell death protein ligand 1 inhibition PMID: 30194079
2. Polymorphisms within the SLC18A gene are associated with asthenozoospermia through sperm count and motility. PMID: 29602729
3. Vmat1 polymorphisms are not associated with suicidal behavior. PMID: 29536333
4. results contribute to the evidence indicating an association between the VMAT1 gene and structural brain alterations in depression. PMID: 28408293
5. VMAT1 rs1390938/Thr136Ile is associated with mood, personality, and alcohol use in the general population. Subjects homozygous for the "hyperfunction" allele (AA; Ile/Ile) appear to be more resilient to these disorders. PMID: 26861143
6. The germline deletions at SLC18A1 contributed to the development of CRC. PMID: 28968818
7. rs2270641 SNP was associated with ASD risk only in over-dominant model. AA genotype of the rs1390938 was protective against ASD under dominant and recessive models. PMID: 28476685
8. Genetic variants in VMAT1 contribute to the severity of alcohol withdrawal in patients of European descent. PMID: 26876819
9. VMAT1 and VMAT2 are expressed in the majority of neuroblastomas PMID: 26338179
10. SLC18A1 gene polymorphisms are associated with the risk of paranoid schizophrenia in Russians and Tatars. PMID: 25842846
11. The data of this study showed that VMAT1 polymorphisms influence monoamine signaling, the functional response of emotional brain circuits and risk for psychopathology. PMID: 23337945
12. Deletion of amino acids 307-338 in hVMAT1 isoform-b abolishes transport activity, and a 136-Thr partially reduces activity of isoform-a. PMID: 23090274
13. we found a significant down-regulation of the gene coding for the vesicular monoamine transporter (VMAT1)in enteroendocrine cells infected with Chlamydia trachomatis PMID: 21883697
14. Human bronchial arterial smooth muscle cells express OCT-1 and extraneuronal monoamine transporter(EMT). EMT is the predominant plasma membrane transporter for norepinephrine uptake. PMID: 12807698
15. Greater expression of VMAT 1 in von Hippel-Lindau syndrome than multiple endocrine neoplasia type 2. Expression of VMAT 2 did not differ significantly. PMID: 16189177
16. VMAT1Delta15 is not localized in large, dense core vesicles as the native form but in the endoplasmic reticulum. While VMAT1 can take up serotonin, VMAT1Delta15 cannot, indicating different functions for the two forms of VMAT1. PMID: 16326835
17. Expression analysis confirmed that VMAT1 is expressed in human brain at the mRNA and protein level. Results suggest that variations in the VMAT1 gene may confer susceptibility to Bipolar Disorder in patients of European descent. PMID: 16936705
18. Our findings support the hypothesis that anxiety-related personality traits are associated with variation in the VMAT1/SLC18A1 gene. PMID: 18249496
19. Polymorphism in VMAT1 gene on chromosome 8p is associated with schizophrenia. PMID: 18451639

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HGNC: 10934

OMIM: 193002

KEGG: hsa:6570

STRING: 9606.ENSP00000276373

UniGene: Hs.158322