SLC25A23 Antibody

Code CSB-PA021492GA01HU
Size US$685
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Product Details

Uniprot No. Q9BV35
Target Names SLC25A23
Alternative Names SLC25A23 antibody; APC2 antibody; MCSC2 antibody; SCAMC3Calcium-binding mitochondrial carrier protein SCaMC-3 antibody; Mitochondrial ATP-Mg/Pi carrier protein 2 antibody; Mitochondrial Ca(2+)-dependent solute carrier protein 2 antibody; Small calcium-binding mitochondrial carrier protein 3 antibody; Solute carrier family 25 member 23 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human SLC25A23
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane
Gene References into Functions
  1. direct measurements of Mg(2+), Mn(2+), Fe(2+), Zn(2+) and Cu(2+) showed that they are cotransported with ATP by both hAPCs and AtAPCs. It is likely that in vivo APCs transport free ATP and ATP-Mg complex to different degrees, and probably trace amounts of other Metals(2+) in complex with ATP. PMID: 28695448
  2. Our results showed EZH2 to be highly overexpressed in astrocytic tumors with a significant positive correlation with grade.we identified SLC25A23 as important target of H3K27me3 modification, which was downregulated in GBM and its low expression was associated with poor prognosis in glioblastomas (GBMs). PMID: 27993893
  3. SLC25A23 augments mitochondrial Ca(2) uptake, interacts with MCU, and induces oxidative stress-mediated cell death. PMID: 24430870
  4. SCaMC-3 is a member of a novel human subfamily of mitochondrial carriers with calcium-binding domains PMID: 15054102
  5. identification of three isoforms of the mitochondrial ATP-Mg/Pi carrier APC1, APC2 and APC3; they are most likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria PMID: 15123600
  6. Northern blot analysis reveals the presence of the transcript in brain, heart, skeletal muscle, liver and small intestine. The SLC25A23 gene undergoes alternative splicing suggesting a modular nature of the encoded product. PMID: 15716113

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Subcellular Location Mitochondrion inner membrane, Multi-pass membrane protein
Protein Families Mitochondrial carrier (TC 2.A.29) family
Tissue Specificity Present in various cell lines (at protein level). Expressed at low levels in most tissues examined, with highest expression in brain, skeletal muscle and pancreas.
Database Links

HGNC: 19375

OMIM: 608746

KEGG: hsa:79085

UniGene: Hs.356231

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