SLC29A4 Antibody

Code CSB-PA132903
Size US$299
Image
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: CSB-PA132903(SLC29A4 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
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Product Details

Uniprot No. Q7RTT9
Target Names SLC29A4
Alternative Names SLC29A4 antibody; ENT4 antibody; PMAT antibody; PSEC0113 antibody; Equilibrative nucleoside transporter 4 antibody; hENT4 antibody; Plasma membrane monoamine transporter antibody; Solute carrier family 29 member 4 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Fusion protein of Human SLC29A4
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,WB
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In
Gene References into Functions
  1. Cultured astroctye line 1321N1 and primary human astrocytes transport monoamines predominantly through PMAT. PMID: 24471494
  2. Transport kinetic analysis revealed that I89M mutant in PMAT protein had a 2.7-fold reduction in maximal transport velocity with no significant change in apparent binding affinity. PMID: 22562044
  3. Data show that ENT1, ENT2, ENT4 and CNT3 protein was detected on ovarian carcinoma cells in all effusions, with expression observed in 1-95% of tumor cells. PMID: 21822668
  4. The selectivity and kinetics of monoamine neurotransmitter transport by PMAT and OCT3 was determined. PMAT is expressed at much higher levels than hOCT3 in brain, whereas hOCT3 is selectively and highly expressed in adrenal gland and skeletal muscle. PMID: 20858707
  5. Observational study of gene-disease association. (HuGE Navigator) PMID: 20392501
  6. may be a novel low affinity transporter for biogenic amines, might supplement the high affinity transporters in the brain PMID: 15448143
  7. PMAT can function as a polyspecific organic cation transporter, which may play a role in organic cation transport in vivo. PMID: 16099839
  8. ENT4, in addition to playing roles in cardiac serotonin transport, contributes to the regulation of extracellular adenosine concentrations, in particular under the acidotic conditions associated with ischemia. PMID: 16873718
  9. our data suggest that PMAT is expressed on the apical membranes of renal epithelial cells and may use luminal proton gradient to drive organic cation reabsorption in the kidney. PMID: 17018840
  10. Amino acid substitution at several sites results in loss of activity ane conformation. PMID: 17121826
  11. PMAT, EMT, and OCT2 transporters are expressed in the endometrial stroma and can potentially regulate reuptake of monoamines in general and histamine in particular. PMID: 17393420
  12. identification of ENT4 as a highly expressed transcript in desmoplastic small round cell tumor (DSRCT) may represent an attractive pathway for targeting chemotherapeutic drugs into DSRCT PMID: 18523561
  13. The data suggest that PMAT is specifically expressed in podocytes and may play an important role in puromycin aminonucleoside-induced kidney injury. PMID: 19357181

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Subcellular Location Cell membrane, Multi-pass membrane protein, Apical cell membrane, Multi-pass membrane protein
Protein Families SLC29A/ENT transporter (TC 2.A.57) family
Tissue Specificity Expressed abundantly in the heart, in both cardiomyocytes and vascular endothelial cells (at protein level). Highly expressed in brain, kidney and skeletal muscle. In the brain expressed in cerebellum, cerebral cortex, medulla, occipital pole, frontal and
Database Links

HGNC: 23097

OMIM: 609149

KEGG: hsa:222962

STRING: 9606.ENSP00000297195

UniGene: Hs.4302

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