SLC30A3 Antibody

1. ZNT3 was only detected in human beta-cells, but not in mouse beta-cells. PMID: 29372370
2. SNPs in the SLC30A3 gene and adjacent region are associated with schizophrenia in female but not male cases. PMID: 27750116
3. There was a significant decreased in protein levels of ZnT3 in the prefrontal cortex in Major depression disorder, relative to control subjects. PMID: 27661418
4. The level of ERK1/2 phosphorylation was significantly increased by tunicamycin treatment in control cells, not in SLC30A3 knockdown cells. The ERK1/2 pathway is thought to have an association with defensive effects of SLC30A3 on cellular stress such as ER stress. PMID: 27678294
5. ZNT3 and ZNT8 (known to regulate insulin secretion) have opposite effects on insulin synthesis and secretion possibly by a transcriptional co-regulation since mRNA expression of ZNT3 was inversely correlated to ZNT8 and ZNT3 over-expression reduced insulin synthesis and secretion. PMID: 26867900
6. An association was found between reduced ZnT3 in the prefrontal cortex and cognitive impairment in patients with either dementia with Lewy bodies or Parkinson's disease dementia. PMID: 25104558
7. SNPs in SLC30A3 show a gender-specific association with schizophrenia in an East UK cohort. PMID: 23849395
8. this study provides the first evidence of a role for zinc in depression in people with dementia. PMID: 24953873
9. The results of this study suggested that ZnT3 protein levels are decreased in the spinal cords of sporadic ALS patients. PMID: 25284286
10. hZnT-3 is expressed at low levels in leukocytes. PMID: 17971500
11. Data show that ZNT3 is extensively present in the Abeta-positive plaques in the cortex of human AD brains. PMID: 18639746
12. SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity PMID: 19521526

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HGNC: 11014

OMIM: 602878

KEGG: hsa:7781

STRING: 9606.ENSP00000233535

UniGene: Hs.467981