SLC31A2 Antibody

Code CSB-PA021577LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA021577LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA021577LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA021577LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC31A2 Polyclonal antibody
Uniprot No.
Target Names
SLC31A2
Alternative Names
SLC31A2; COPT2; CTR2; Probable low affinity copper uptake protein 2; Copper transporter 2; hCTR2; Solute carrier family 31 member 2
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Probable low affinity copper uptake protein 2 protein (44-93AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SLC31A2 Antibody (Product code: CSB-PA021577LA01HU) is Non-conjugated. For SLC31A2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA021577LB01HU SLC31A2 Antibody, HRP conjugated ELISA
FITC CSB-PA021577LC01HU SLC31A2 Antibody, FITC conjugated
Biotin CSB-PA021577LD01HU SLC31A2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in low-affinity copper uptake.
Gene References into Functions
  1. 11 single-nucleotide polymorphisms (SNPs) in CTR1, CTR2, ATP7A, and ATP7B were genotyped in these patients. PMID: 28737129
  2. Decreased expression of CTR2 is associated with clear cell renal cell carcinoma. PMID: 26411550
  3. Over-expression of CTR2 increased exchangeable Cu(+) by 150% and rendered the human epithelial 2008 cancer cell model 2.5-fold resistant to cisplatin. PMID: 24522273
  4. Increased CTR2 expression is associated with platinum resistance in epithelial ovarian cancer. PMID: 23564780
  5. hCTR2 is as an oligomeric membrane protein localized in lysosomes, which stimulates copper delivery to the cytosol of human cells at relatively high copper concentrations. PMID: 17617060
  6. Ctr2 promotes copper uptake at the plasma membrane and plays a role in regulating copper levels in COS-7 cells PMID: 17944601
  7. CTR2 functions by limiting drug accumulation, and its expression correlates with the sensitivity of human ovarian carcinoma cell lines to cisplatin. PMID: 19509135

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Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Copper transporter (Ctr) (TC 1.A.56) family, SLC31A subfamily
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 11017

OMIM: 603088

KEGG: hsa:1318

STRING: 9606.ENSP00000259392

UniGene: Hs.24030

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