SLC38A4 Antibody

Code CSB-PA021619GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SLC38A4
Alternative Names
SLC38A4 antibody; ATA3 antibody; NAT3 antibody; SNAT4 antibody; Sodium-coupled neutral amino acid transporter 4 antibody; Amino acid transporter A3 antibody; Na(+)-coupled neutral amino acid transporter 4 antibody; Solute carrier family 38 member 4 antibody; System A amino acid transporter 3 antibody; System N amino acid transporter 3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SLC38A4
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Applications : Western blot

Sample type: cells

Review: Western blotting analysis for CYP11A1, CYP19A1, HSD3b1, STAR, FSHR, LHCGR, and SNAT4 in rGCs after methionine supplementation.

By Anonymous

Target Background

Function
Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.
Gene References into Functions
  1. three SNPs (corepressor interacting with RBPJ 1 (CIR1) rs13009079T>C, ribonucleotide reductase M1 (RRM1) rs1465952T>C and solute carrier family 38, member 4 (SLC38A4) rs2429467C>T), may play a role in the pathogenesis of lung cancer PMID: 27587543
  2. PAAT is a novel ATPase and a trans-regulator of mitochondrial ABC transporters that plays an important role in the maintenance of mitochondrial homeostasis PMID: 25063848
  3. Our results suggest that mutant allele A for SNP 1304 G>A of SLC38A4 gene is associated with hyperglycaemia. PMID: 22945694
  4. Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein PMID: 21917917
  5. evidence of SNAT4 mRNA and protein expression in the human placenta, both at the first trimester and at full term PMID: 16148032
  6. Report SNAT4 activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
  7. the contribution of SNAT4 to system A-mediated placental microvillous transport decreases between first trimester and term PMID: 19015196

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Amino acid/polyamine transporter 2 family
Tissue Specificity
Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas. Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels.
Database Links

HGNC: 14679

OMIM: 608065

KEGG: hsa:55089

STRING: 9606.ENSP00000266579

UniGene: Hs.446077

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