SLC4A5 Antibody

Code CSB-PA874837LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Hela whole cell lysate, U87 whole cell lysate
    All lanes: SLC4A5 antibody at 2.7μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 127, 125, 116, 109, 108, 114, 119 kDa
    Observed band size: 127 kDa

  • Immunofluorescence staining of HepG2 cells with CSB-PA874837LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC4A5 Polyclonal antibody
Uniprot No.
Target Names
SLC4A5
Alternative Names
Electrogenic sodium bicarbonate cotransporter 4 antibody; MGC129662 antibody; NBC4 antibody; NBCe2 antibody; S4A5_HUMAN antibody; SLC4A5 antibody; Solute carrier family 4 member 5 antibody; Solute carrier family 4 sodium bicarbonate cotransporter member 5 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Electrogenic sodium bicarbonate cotransporter 4 protein (1071-1137AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SLC4A5 Antibody (Product code: CSB-PA874837LA01HU) is Non-conjugated. For SLC4A5 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA874837LB01HU SLC4A5 Antibody, HRP conjugated ELISA
FITC CSB-PA874837LC01HU SLC4A5 Antibody, FITC conjugated
Biotin CSB-PA874837LD01HU SLC4A5 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.
Gene References into Functions
  1. NBCe2 activity is stimulated by an increase in intracellular sodium and is hyper-responsive in hRPTCs carrying HV SLC4A5 rs7571842 through an aberrant HNF4A-mediated mechanism PMID: 29642240
  2. NBCe2 could be important in proximal kidney tubule apical sodium and bicarbonate cotransport under high-salt conditions. PMID: 26447209
  3. we summarize the potential function of NBCe2 in the regulation of blood pressure, acid-base, and K(+) and Ca(2+) transport in the distal nephron--{REVIEW} PMID: 26136555
  4. Data indicate that 2 SNPs in SLC4A5 (rs7571842 and rs10177833) showed highly significant results and large effects sizes. PMID: 22987918
  5. The additive effect of rs10177833 of SLC4A5 on systolic blood pressure is statistically different between women with dark skin color and women with medium skin color (P = .0153). PMID: 22764636
  6. Summarizing, the observed associations with resting and submaximal-exercise cardiovascular and metabolic traits in the HERITAGE Family Study are likely due to neither variation in the promoter nor known coding SNPs of SLC4A5 PMID: 19384345
  7. Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued). PMID: 12063394
  8. These results additionally confirm the involvement of SLC4A5 with blood pressure control, although the mechanism is still unclear. PMID: 16365189

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Subcellular Location
Apical cell membrane; Multi-pass membrane protein.
Protein Families
Anion exchanger (TC 2.A.31) family
Tissue Specificity
Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach a
Database Links

HGNC: 18168

OMIM: 606757

KEGG: hsa:57835

STRING: 9606.ENSP00000350475

UniGene: Hs.594099

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