SLC6A12 Antibody

Datasheet

Code	CSB-PA021690ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA021690ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA021690ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC6A12 Polyclonal antibody

Uniprot No.

P48065

Target Names

SLC6A12

Alternative Names

Betaine/GABA transporter 1 antibody; BGT-1 antibody; BGT1 antibody; Gamma aminobutyric acid transporter antibody; GAT2 antibody; Na(+)/Cl(-) betaine/GABA transporter antibody; S6A12_HUMAN antibody; Slc6a12 antibody; Sodium- and chloride-dependent betaine transporter antibody; Solute carrier family 6 (neurotransmitter transporter), member 12 antibody; Solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 antibody; Solute carrier family 6 member 12 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Sodium- and chloride-dependent betaine transporter protein (515-614AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.

Gene References into Functions

The SLC6A12 expression levels in peripheral blood mononuclear cells were significantly higher in TLE patients. PMID: 26690518
T40 may be important for the trafficking and insertion of BGT1 in the plasma membrane PMID: 24829506
JAK2 is a novel regulator of the GABA transporter BGT1. PMID: 22405821
This study found that rs216250 of SLC6A12 was correlated with the Scale for the Assessment of Negative Symptoms (SANS) scores. PMID: 21367462
Results showed that two polymorphisms and a haplotype in SLC6A12, were significantly associated with AIA after multiple testing corrections. PMID: 20597903
The primary structure of BGT-1 predicts two putative phosphorylation sites for the Ca2+/diacylglycerol-dependent protein kinase (PKC), which regulates BGT-1 function by phosphorylation events in a transport system expressed in cultured astrocytoma cells. PMID: 12111824
BGT-1 is expressed from mRNA and transports GABA in platelets. PMID: 16198020

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Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A12 subfamily

Tissue Specificity

Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.

Database Links

HGNC: 11045

OMIM: 603080

KEGG: hsa:6539

STRING: 9606.ENSP00000352702

UniGene: Hs.437174

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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