SLC7A1 Antibody

1. Estradiol increases arginine transport and CAT-1 activity through modulation of constitutive signaling transduction pathways involving ERK. Progesterone inhibits arginine transport and CAT-1 via both PKCalpha and ERK1/2 phosphorylation. PMID: 26062636
2. The rs41318021 polymorphism in the SLC7A1 gene was not associated with essential hypertension in 50-year-old subjects. PMID: 23841815
3. Overexpression of arginine transporter CAT-1 is associated with accumulation of L-arginine and cell growth in human colorectal cancer tissue. PMID: 24040099
4. CAT1, CAT2, and CAT3 localized in adult brains but with uneven distribution. PMID: 22870827
5. mRNA levels for high-affinity CAT-1, expressed as a percentage of the wild-type value, are increased by an average 12% and 32% in mdx and transgenic mdx:utr mice respectively. PMID: 23009292
6. The data demonstrates that CAT1 significantly (but most likely not exclusively) contributes to the cellular uptake of asymmetric dimethylarginine. PMID: 22705145
7. In hypoxic human pulmonary microvascular endothelial cells, overexpression of CAT-1 resulted in significantly greater L-arginine transport and NO production PMID: 21923750
8. In acute congestive heart failure acute renal impairment function and the modulation of metabolism and extracellular transport by the DDAH-1/CAT-1 system determine high ADMA and SDMA levels after therapy for acute congestive heart failure. PMID: 21722652
9. Insulin increased hCATs-L-arginine transport, maximal transport capacity, and hCAT-1 expression. Sp1 nuclear protein abundance and binding to DNA, and SLC7A1 promoter activity was increased by insulin. PMID: 21302286
10. Data show that the CAT-1 isoform plays a role in arginine uptake. PMID: 21308737
11. PKC activation also resulted in ubiquitination of CAT-1 PMID: 21212261
12. analysis of the genomic organization PMID: 11665818
13. Stable polarized expression of hCAT-1 in an epithelial cell line. PMID: 11891586
14. Keratinocytes express cationic amino acid transporters 1 and 2. Cationic amino acid transporter mediated L-arginine essential for inducible nitric oxide synthase and arginase enzyme, which modulate proliferation and differentiation of epidermal cells. PMID: 12787129
15. Insulin-mediated stimulation of the L-arginine/NO pathway is thus associated with increased hCAT-1 and hCAT-2B mRNA, and eNOS expression PMID: 15064952
16. Glomerular arginine uptake is elevated through modulation of CAT-1 expression, thus, contributing to the pathogenesis of hyperfiltration. Increased nitric oxide formation may play a role in this process. PMID: 15086470
17. protein kinase C(PKC) did not phosphorylate human cationic amino acid transporter hCAT-1 directly as evidenced by in vivo phosphorylation experiments and mutational analysis, indicating an indirect action of PKC on hCAT-1 PMID: 15491978
18. The CAT-1 is thought to supply substrate to endothelial NOS by virtue of its co-localisation with this enzyme. PMID: 15631944
19. The present study identifies a key functionally active polymorphism in the 3'UTR of SLC7A1 [which] may account for the apparent link between altered endothelial function, L-arginine, and nitric oxide metabolism and predisposition to essential hypertension PMID: 17325243
20. Ornithine uptake in retinal pigment epithelium is depdendent on induction of SLC7A1 mRNA and spermine. PMID: 17494634
21. distribution of human cationic amino acid transporters 1 (hCAT1) and 2 (hCAT2) in healthy skin and compared it to psoriatic skin lesions by means of immunohistochemistry PMID: 18172665
22. CAT1 is directly involved in erythropoiesis through supplying arginine to the blood cells. PMID: 18574322
23. Data provide novel insights into the mechanism by which ss52051869 influences SLC7A1 gene expression. PMID: 19067360

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HGNC: 11057

OMIM: 104615

KEGG: hsa:6541

STRING: 9606.ENSP00000370128

UniGene: Hs.14846