SLC7A2 Antibody

Datasheet

Code	CSB-PA021714LA01HU
Size	US$166
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Image	IHC image of CSB-PA021714LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC7A2 Polyclonal antibody

Uniprot No.

P52569

Target Names

SLC7A2

Alternative Names

ATRC2 antibody; 20.5 antibody; Amino acid transporter; cationic 2 (low affinity) antibody; ATRC 2 antibody; CAT 2 antibody; CAT-2 antibody; CAT2 antibody; Cat2a antibody; Cat2b antibody; Cationic amino acid transporter 2A antibody; cationic amino acid transporter; y+ system; low affinity cationic amino acid transporter 2 antibody; CTR2_HUMAN antibody; HCAT 2 antibody; HCAT2 antibody; Low affinity cationic amino acid transporter 2 antibody; OTTHUMP00000216432 antibody; OTTHUMP00000216433 antibody; OTTMUSP00000041667 antibody; OTTMUSP00000041669 antibody; RCAT2 antibody; SLC7A 2 antibody; Slc7a2 antibody; Solute carrier family 7 member 2 antibody; T cell early activation protein antibody; Tea antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cationic amino acid transporter 2 protein (604-658AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SLC7A2 Antibody (Product code: CSB-PA021714LA01HU) is Non-conjugated. For SLC7A2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA021714LB01HU	SLC7A2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA021714LC01HU	SLC7A2 Antibody, FITC conjugated
Biotin	CSB-PA021714LD01HU	SLC7A2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). May play a role in classical or alternative activation of macrophages via its role in arginine transport.

Gene References into Functions

genetic association studies in population in Tennessee: Data suggest that an SNP in SLC7A2 (rs2720574) is associated with response to dietary calcium and magnesium in prevention of colorectal polyps and colorectal ademonas. PMID: 28501704
Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide. PMID: 24019517
A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport. PMID: 22787143
Addition of spermine or knockdown of CAT2 inhibited L-Arg uptake, NO production, and iNOS protein levels, whereas knockdown of ODC had the opposite effect. CAT2 and ODC were increased in mouse and human H pylori gastritis tissues. PMID: 20600019
Insulin increased L-arginine transport and the mRNA levels for hCAT-1 and hCAT-2B PMID: 15064952

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2.A.3.3) family

Tissue Specificity

Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart.

Database Links

HGNC: 11060

OMIM: 601872

KEGG: hsa:6542

STRING: 9606.ENSP00000004531

UniGene: Hs.448520

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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