SLC7A2 Antibody, HRP conjugated

Datasheet

Code	CSB-PA021714LB01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC7A2 Polyclonal antibody

Uniprot No.

P52569

Target Names

SLC7A2

Alternative Names

ATRC2 antibody; 20.5 antibody; Amino acid transporter; cationic 2 (low affinity) antibody; ATRC 2 antibody; CAT 2 antibody; CAT-2 antibody; CAT2 antibody; Cat2a antibody; Cat2b antibody; Cationic amino acid transporter 2A antibody; cationic amino acid transporter; y+ system; low affinity cationic amino acid transporter 2 antibody; CTR2_HUMAN antibody; HCAT 2 antibody; HCAT2 antibody; Low affinity cationic amino acid transporter 2 antibody; OTTHUMP00000216432 antibody; OTTHUMP00000216433 antibody; OTTMUSP00000041667 antibody; OTTMUSP00000041669 antibody; RCAT2 antibody; SLC7A 2 antibody; Slc7a2 antibody; Solute carrier family 7 member 2 antibody; T cell early activation protein antibody; Tea antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cationic amino acid transporter 2 protein (604-658AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). May play a role in classical or alternative activation of macrophages via its role in arginine transport.

Gene References into Functions

genetic association studies in population in Tennessee: Data suggest that an SNP in SLC7A2 (rs2720574) is associated with response to dietary calcium and magnesium in prevention of colorectal polyps and colorectal ademonas. PMID: 28501704
Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide. PMID: 24019517
A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport. PMID: 22787143
Addition of spermine or knockdown of CAT2 inhibited L-Arg uptake, NO production, and iNOS protein levels, whereas knockdown of ODC had the opposite effect. CAT2 and ODC were increased in mouse and human H pylori gastritis tissues. PMID: 20600019
Insulin increased L-arginine transport and the mRNA levels for hCAT-1 and hCAT-2B PMID: 15064952

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2.A.3.3) family

Tissue Specificity

Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart.

Database Links

HGNC: 11060

OMIM: 601872

KEGG: hsa:6542

STRING: 9606.ENSP00000004531

UniGene: Hs.448520

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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