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Product Name:

SMARCC2 Antibody

Code : CSB-PA851527ESR2HU
Size : US$167Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot NO. : Q8TAQ2
Storage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Image :
  • All lanes: SWI/SNF complex subunit SMARCC2 antibody at 2ug/ml+mouse liver tissue
    Secondary
    Goat polyclonal to rabbit at 1/10000 dilution
    Predicted band size: 133,125,127 kDa
    Observed band size: 133 kDa

  • Immunohistochemistry of paraffin-embedded human rectal cancer using CSB-PA851527ESR2HU at dilution 1:100

  • Immunohistochemistry of paraffin-embedded human epityphlon using CSB-PA851527ESR2HU at dilution 1:100

  • Immunohistochemistry of paraffin-embedded human tonsil using CSB-PA851527ESR2HU at dilution 1:100

  • Chromatin Immunoprecipitation Hela(1.1*106)were cross-linked with formaldehyde, sonicated, and immunoprecipitated with 4ug anti-SMARCC2 or a control normal rabbit IgG . The resulting ChIP DNA was quantified using real-time PCR with primers (CSB-PP851527HU) against the ESR1 pS2 promoter.

Immunogen : Recombinant human SWI/SNF complex subunit SMARCC2 protein (300-650AA)
Raised in : Rabbit
Species Reactivity : Human,Mouse
Tested Applications : ELISA,WB,IHC,ChIP;Recommended dilution:WB:1:1000-1:5000,IHC:1:20-1:200
Relevance : Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth
Form : Liquid
Conjugate : Non-conjugated
Storage Buffer : PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification method : Antigen Affinity Purified
Isotype : IgG
Clonality : Polyclonal
Alias : BRG1-associated factor 170,BAF170,SWI/SNF complex 170 kDa subunit,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2,SMARCC2,BAF170
Species : Human
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