SMARCC2 Antibody

Code CSB-PA851527LA11HU
Size US$166
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Image
  • IHC image of CSB-PA851527LA11HU diluted at 1:200 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • Immunofluorescence staining of A549 cells with CSB-PA851527LA11HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SMARCC2 Polyclonal antibody
Uniprot No.
Target Names
SMARCC2
Alternative Names
SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2), SMARCC2, BAF170
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human SWI/SNF complex subunit SMARCC2 protein (300-647aa)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SMARCC2 Antibody (Product code: CSB-PA851527LA11HU) is Non-conjugated. For SMARCC2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA851527LB11HU SMARCC2 Antibody, HRP conjugated ELISA
FITC CSB-PA851527LC11HU SMARCC2 Antibody, FITC conjugated
Biotin CSB-PA851527LD11HU SMARCC2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:500
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
Gene References into Functions
  1. BAF170 is important for neurogenesis in embryonic olfactory epithelium. PMID: 27611684
  2. Identification of frameshift mutations in the SMARCC2 gene in gastric and colorectal cancers with microsatellite instability. PMID: 23030715
  3. study finds Baf53 and Baf170 are highly regulated in HIV-1-infected cells PMID: 21699904
Subcellular Location
Nucleus.
Protein Families
SMARCC family
Tissue Specificity
Ubiquitously expressed.
Database Links

HGNC: 11105

OMIM: 601734

KEGG: hsa:6601

STRING: 9606.ENSP00000267064

UniGene: Hs.236030

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