SMARCD2 Antibody, Biotin conjugated

Code CSB-PA846114LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SMARCD2 Polyclonal antibody
Uniprot No.
Target Names
SMARCD2
Alternative Names
SMARCD2 antibody; BAF60B antibody; PRO2451 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 antibody; 60 kDa BRG-1/Brm-associated factor subunit B antibody; BRG1-associated factor 60B antibody; BAF60B antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 protein (1-113AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
Gene References into Functions
  1. Data show that both CEBPE and SMARCD2 loss-of-function mutations identified in patients with neutrophil-specific granule deficiency (SGD) abolish the interaction with SWI/SNF and secondary granule gene expression, thus providing a molecular basis for this disease. PMID: 28369034
  2. Defective expression of SMARCD2 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily D, member 2) leads to transcriptional and chromatin changes in acute myeloid leukemia (AML) promyelocytic cells, suggesting SMARCD2 is a key factor controlling myelopoiesis and is a potential tumor suppressor in leukemia. PMID: 28369036
  3. the Rac- and Unkempt-dependent process leading to BAF60b ubiquitination takes place in the nuclear compartment PMID: 20148946
Involvement in disease
Specific granule deficiency 2 (SGD2)
Subcellular Location
Nucleus.
Protein Families
SMARCD family
Tissue Specificity
Isoform 2 is expressed in the pancreas.
Database Links

HGNC: 11107

OMIM: 601736

KEGG: hsa:6603

STRING: 9606.ENSP00000392617

UniGene: Hs.250581

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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