SNAPIN Antibody

1. These observations suggest an important role for SNAPIN and autophagy in the homeostasis of macrophages, particularly long-lived tissue resident macrophages. PMID: 27929705
2. These results provide the evidence of a direct regulatory role of Snapin on Cav1.3 channels in atrial myocytes. PMID: 27915047
3. Inhibition of Snapin enhanced localization of HIV-1 with TLR8(+) early endosomes, triggered a pro-inflammatory response, and inhibited trans-infection of CD4(+) T cells. PMID: 28923824
4. Taken together, these results suggest that Snapin, the pUL130 interacting protein, has a role in modulating HCMV DNA synthesis. PMID: 27240978
5. Disruption of Snapin-PKR2 interaction did not affect PKR2 signaling, but increased the ligand-induced degradation, implying a role of Snapin in the trafficking of PKR2. PMID: 26687946
6. Authors propose that Snapin connects chlamydial inclusions with the microtubule network by interacting with both Chlamydia psittaci IncB and dynein. PMID: 24751478
7. Snapin, a SNAP-25 (synaptosomal-associated protein-25) interacting protein, interacts with LRRK2. PMID: 23949442
8. These observations identify Snapin as a novel endogenous TLR2 ligand in rheumatoid arthritis, and thus support a role for persistent TLR2 signalling in pathogenesis. PMID: 22523426
9. These results suggest that Snapin may play a key role in regulating the cellular localization of human cytomegalovirus UL70, leading to modulation of viral DNA synthesis and progeny production. PMID: 21917956
10. PKA-dependent phosphorylation of snapin increases interaction among insulin secretory vesicle-associated proteins, thereby potentiating glucose-stimulated insulin secretion. PMID: 21356520
11. results suggest that RGS7 could play a role in synaptic vesicle exocytosis through its interaction with snapin PMID: 12659861
12. EBAG9 and Snapin have roles in controlling exocytosis processes PMID: 15635093
13. results demonstrate that snapin is a binding partner of dysbindin-1 in vitro and in the brain; both dysbindin-1 and snapin are concentrated in tissue enriched in synaptic vesicle membranes and less commonly in postsynaptic densities PMID: 16980328
14. Snapin links the alpha(1A)-AR to TRPC6, augmenting Ca(2+) influx via ROC channels PMID: 17684020
15. Data describe for the first time the expression of SNAPIN in germ cells which raises possibility that SNAPIN plays an extra role in mammals which is germ cell specific. PMID: 19168546
16. Snapin plays an important role as a linker between the water channel and the t-SNARE complex, leading to the fusion event, and the pairing with specific t-SNAREs is essential for the specificity of membrane recognition and fusion. PMID: 19515809

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HGNC: 17145

OMIM: 607007

KEGG: hsa:23557

STRING: 9606.ENSP00000357674

UniGene: Hs.32018