SNRPA Antibody

Datasheet

Code	CSB-PA00974A0Rb
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA00974A0Rb at dilution of 1:100 Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA00974A0Rb at dilution of 1:100 Western blot All lanes:SNRPA antibody at 9μg/ml + Mouse liver tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 31 kDa Observed band size: 31 kDa Immunofluorescent analysis of Hela cells using CSB-PA00974A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SNRPA Polyclonal antibody

Uniprot No.

P09012

Target Names

SNRPA

Alternative Names

fc19d01 antibody; Mud1 antibody; small nuclear ribonucleoprotein polypeptide A antibody; snRNP A antibody; snRNP protein A antibody; SNRPA antibody; SNRPA_HUMAN antibody; U1 small nuclear ribonucleoprotein A antibody; U1 small nuclear RNP specific A antibody; U1 snRNP A antibody; U1 snRNP specific protein A antibody; U1-A antibody; U1A antibody; wu:fc19d01 antibody; zgc:77810 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human U1 small nuclear ribonucleoprotein A protein (8-278AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SNRPA Antibody (Product code: CSB-PA00974A0Rb) is Non-conjugated. For SNRPA Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA00974B0Rb	SNRPA Antibody, HRP conjugated	ELISA
FITC	CSB-PA00974C0Rb	SNRPA Antibody, FITC conjugated
Biotin	CSB-PA00974D0Rb	SNRPA Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.

Gene References into Functions

SNRPA may contribute to GC progression via NGF and could be a prognostic biomarker for GC. PMID: 30039889
p65 activation triggered by TCR signaling could promote SNRPA transcription and 3' UTR shortening of STAT5B. Thus we propose that the alternative polyadenylation switching of STAT5B induced by TCR activation is mediated by SNRPA. PMID: 28954886
a new mechanism for regulating SMN levels and provides new insight into the roles of U1A in 3' processing of mRNAs. PMID: 24362020
An analysis of the kinetic data suggests three phases of U1A-SL2 RNA complex dissociation with time scales of approximately 100 mus, approximately 50 ms, and approximately 2 s. We propose that the first step of dissociation is a fast rearrangement of the complex to form a loosely bound complex. PMID: 21419778
structural analysis of U1A protein-stem loop 2 RNA recognition PMID: 21384338
study shows that the yellow fever virus (YFV) NS5 protein is able to interact with U1A, a protein involved in splicing and polyadenylation; a region between amino acids 368 and 448 was identified as the site of interaction of the NS5 protein with U1A PMID: 21298455
13)C NMR relaxation studies of base and ribose dynamics for the RNA internal loop target of human U1A protein located within the 3'-untranslated region (3'-UTR) of the mRNA coding for U1A itself PMID: 15890361
Identification of PSF, p54(nrb), PTB, and U1A as proteins specifically bound to the COX-2 polyadenylation signal upstream sequence elements . PMID: 17507659
Functional U1A site in a cellular gene and of a single gene containing two dissimilar elements that inhibit nuclear polyadenylation. PMID: 17942741

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Subcellular Location

Nucleus.

Protein Families

RRM U1 A/B'' family

Database Links

HGNC: 11151

OMIM: 182285

KEGG: hsa:6626

STRING: 9606.ENSP00000243563

UniGene: Hs.466775

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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