SNX33 Antibody, HRP conjugated

Code CSB-PA851969LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SNX33 Polyclonal antibody
Uniprot No.
Target Names
SNX33
Alternative Names
MGC32065 antibody; SH3 and PX domain containing 3 antibody; SH3 and PX domain containing protein 3 antibody; SH3 and PX domain-containing protein 3 antibody; SH3PX3 antibody; SH3PXD3C antibody; SNX 30 antibody; SNX 33 antibody; SNX30 antibody; snx33 antibody; SNX33_HUMAN antibody; Sorting nexin 33 antibody; Sorting nexin-33 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sorting nexin-33 protein (348-516AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.
Gene References into Functions
  1. The sorting nexin 9 (SNX9) subfamily members - SNX9, SNX18 and SNX33 - are required for progression and completion of mitosis. PMID: 22718350
  2. study identifies critical amino acids within the BAR domains of SNX9 and SNX33 as determinants for the specificity of BAR domain-mediated interactions and suggests that SNX9 and SNX33 have distinct molecular functions. PMID: 20964629
  3. Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins SNX33 and nephrocystin PMID: 19718658
  4. identifies SNX33 as a new endocytic protein, which modulates amyloid precursor protein endocytosis and APP alpha-secretase cleavage, and demonstrates that the rate of APP endocytosis is a major control factor for APP alpha-secretase cleavage PMID: 18353773
  5. SNX33 interferes with cellular PrP formation by modulation of PrP shedding PMID: 18419754
  6. SNX33 plays a role in maintaining cell shape and cell cycle progression through its interaction with WASp PMID: 19487689

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Subcellular Location
Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Families
Sorting nexin family
Tissue Specificity
Detected in heart and pancreas.
Database Links

HGNC: 28468

KEGG: hsa:257364

STRING: 9606.ENSP00000311427

UniGene: Hs.8705

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