SNX33 Antibody

Datasheet

Code	CSB-PA851969LA01HU
Size	US$166
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Image	IHC image of CSB-PA851969LA01HU diluted at 1:800 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SNX33 Polyclonal antibody

Uniprot No.

Q8WV41

Target Names

SNX33

Alternative Names

MGC32065 antibody; SH3 and PX domain containing 3 antibody; SH3 and PX domain containing protein 3 antibody; SH3 and PX domain-containing protein 3 antibody; SH3PX3 antibody; SH3PXD3C antibody; SNX 30 antibody; SNX 33 antibody; SNX30 antibody; snx33 antibody; SNX33_HUMAN antibody; Sorting nexin 33 antibody; Sorting nexin-33 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Sorting nexin-33 protein (348-516AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SNX33 Antibody (Product code: CSB-PA851969LA01HU) is Non-conjugated. For SNX33 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA851969LB01HU	SNX33 Antibody, HRP conjugated	ELISA
FITC	CSB-PA851969LC01HU	SNX33 Antibody, FITC conjugated
Biotin	CSB-PA851969LD01HU	SNX33 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

Gene References into Functions

The sorting nexin 9 (SNX9) subfamily members - SNX9, SNX18 and SNX33 - are required for progression and completion of mitosis. PMID: 22718350
study identifies critical amino acids within the BAR domains of SNX9 and SNX33 as determinants for the specificity of BAR domain-mediated interactions and suggests that SNX9 and SNX33 have distinct molecular functions. PMID: 20964629
Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins SNX33 and nephrocystin PMID: 19718658
identifies SNX33 as a new endocytic protein, which modulates amyloid precursor protein endocytosis and APP alpha-secretase cleavage, and demonstrates that the rate of APP endocytosis is a major control factor for APP alpha-secretase cleavage PMID: 18353773
SNX33 interferes with cellular PrP formation by modulation of PrP shedding PMID: 18419754
SNX33 plays a role in maintaining cell shape and cell cycle progression through its interaction with WASp PMID: 19487689

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Subcellular Location

Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

Sorting nexin family

Tissue Specificity

Detected in heart and pancreas.

Database Links

HGNC: 28468

KEGG: hsa:257364

STRING: 9606.ENSP00000311427

UniGene: Hs.8705

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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