SNX5 Antibody, FITC conjugated

Datasheet
Code CSB-PA872015LC01HU
Size US$299
Uniprot No. Q9Y5X3
Protocols ELISA Protocol
Immunogen Recombinant Human Sorting nexin-5 protein (7-245AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941).
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Sorting nexin-5, SNX5
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names SNX5
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2)
Subcellular Location Endosome, Early endosome, Early endosome membrane, Peripheral membrane protein, Cytoplasmic side, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasmic vesicle membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, Cell projection, phagocytic cup, Cell projection, ruffle
Protein Families Sorting nexin family
Database Links

HGNC: 14969

OMIM: 605937

KEGG: hsa:27131

STRING: 9606.ENSP00000366988

UniGene: Hs.316890

Pathway Endocytosis

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