SNX6 Antibody

Code CSB-PA890766LA01HU
Size US$166
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  • Western blot
    All lanes: SNX6 antibody at 4μg/ml + Hela whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 47, 34 kDa
    Observed band size: 47 kDa

  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA890766LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SNX6 Polyclonal antibody
Uniprot No.
Target Names
SNX6
Alternative Names
SNX6 antibody; Sorting nexin-6 antibody; TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6 antibody; N-terminally processed] antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sorting nexin-6 protein (1-290AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SNX6 Antibody (Product code: CSB-PA890766LA01HU) is Non-conjugated. For SNX6 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA890766LB01HU SNX6 Antibody, HRP conjugated ELISA
FITC CSB-PA890766LC01HU SNX6 Antibody, FITC conjugated
Biotin CSB-PA890766LD01HU SNX6 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation. In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B. May contribute to transcription regulation.
Gene References into Functions
  1. study confirms the utility of proximity-labeling methods, such as BioID, to screen for interactors of cell-surface receptors and has uncovered a role of one of these interactors, SNX6, in the IGF1R signaling cascade. PMID: 29530981
  2. These results identify SNX6 as a key regulator of lamin A synthesis and incorporation into the nuclear envelope. PMID: 25535984
  3. Study observed that SNX6 increases BRMS1-dependent transcriptional repression. Moreover, over-expression of SNX6 was capable of diminishing trans-activation in a dose-dependent manner. PMID: 20830743
  4. SNX6 modulates the retrograde trafficking and basal levels of BACE1, thereby regulating BACE1-mediated APP processing and Abeta biogenesis PMID: 20354142
  5. These observations indicate that in addition to SNX1/2, SNX6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates. PMID: 19935774
  6. SNX5 and SNX6 may constitute functional equivalents of Vps17p in mammalian retromer PMID: 17148574

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Subcellular Location
Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm. Nucleus.
Protein Families
Sorting nexin family
Database Links

HGNC: 14970

OMIM: 606098

KEGG: hsa:58533

STRING: 9606.ENSP00000355217

UniGene: Hs.276523

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