SNX9 Antibody

1. In conclusion, the authors identified SNX9 as a facilitator of podocin endocytosis in severe podocyte injury and demonstrated the expression of SNX9 in the podocytes of both nephropathy model mice and human patients with irreversible glomerular disease. PMID: 28266622
2. The diversified changes associated with SNX9 expression in cancer highlight its importance as a central regulator of cancer cell behavior. PMID: 27278018
3. reduced levels of SNX9 were observed in blood samples from colorectal cancer patients, emphasizing the feasibility of its use as a diagnostic and prognostic biomarker sensing the host's immune status and inflammatory stage. PMID: 26608909
4. this study shows that SNX9 uses a unique mechanism to induce the tubulation of the plasma membrane which mediates proper membrane deformation during clathrin-mediated endocytosis. PMID: 25256216
5. SNX9 and CHC function in the same molecular pathway for chromosome alignment and segregation, which is dependent on their direct association. PMID: 23861900
6. The sorting nexin 9 (SNX9) subfamily members - SNX9, SNX18 and SNX33 - are required for progression and completion of mitosis. PMID: 22718350
7. study identifies critical amino acids within the BAR domains of SNX9 and SNX33 as determinants for the specificity of BAR domain-mediated interactions and suggests that SNX9 and SNX33 have distinct molecular functions. PMID: 20964629
8. Findings suggest that EspF promotes EPEC invasion of intestinal epithelial cells by harnessing the membrane-deforming activity of SNX9. PMID: 20088948
9. The interaction with SNX9 is mediated by the proline-rich domain (PRD) of Itch, a domain distinct from the conventional WW recognition domain, and the SH3 domain of SNX9. PMID: 20491914
10. SNX9 binding to aldolase is structurally precluded by the binding of substrate to the active site. PMID: 20129922
11. The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation PMID: 11799118
12. SNX9 may function to assist AP-2 in its role at the plasma membrane. PMID: 11879186
13. SNX9 may be recruited together with dynamin-2 and become co-assembled with AP-2 and clathrin at the plasma membrane PMID: 12952949
14. SNX9-dependent recruitment of Dyn2 to the membrane is regulated by an interaction between SNX9 and aldolase PMID: 15299020
15. SNX9 is required for efficient clathrin-mediated endocytosis and suggest that it functions to regulate dynamin activity PMID: 15703209
16. Dimerization, which is mediated by the BAR domain, is essential for the intracellular function of SH3PX1. PMID: 16316319
17. identified sorting nexin 9 (SNX9) as a host cell enteropathogenic E. coli EspF binding partner protein, which binds EspF via its amino-terminal SH3 region PMID: 16585770
18. the WASp/SNX9/p85/CD28 complex enables a unique interface of endocytic, actin polymerizing, and signal transduction pathways required for CD28-mediated T cell costimulation PMID: 17242350
19. SNX9 is directly involved in coupling actin dynamics to achieve membrane remodeling during multiple modes of endocytosis PMID: 17609109
20. SNX9 PX and BAR domains work in concert in targeting and tubulation of phosphoinositide-containing membranes. PMID: 17948057
21. crystallization and x-ray diffraction of SNX9 PMID: 18065239
22. SNX9 functions in the coordination of membrane remodeling and fission via interactions with actin-regulating proteins, endocytic proteins and PtdIns(4,5)P2-metabolizing enzymes PMID: 18388313
23. Tip-to-tip interactions between the BAR domains in a trigonal crystal form of Snx9(PX-BAR) reminiscent of functionally important interactions described for F-BAR domains. PMID: 18940612

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HGNC: 14973

OMIM: 605952

KEGG: hsa:51429

STRING: 9606.ENSP00000376024

UniGene: Hs.191213