SOCS6 Antibody

1. Together, our data provide important evidence for miR-19 mediated SOCS6 in OS growth and revealed miR-19/SOCS6/JAK2/STAT3 pathway as a potential therapeutic strategy for OS patients. PMID: 28986253
2. Results indicate that similar to PTEN pseudogene (PTENP1), suppressor of cytokine signaling 6 protein (SOCS6) expression was also significantly lower in esophageal squamous cell carcinoma (ESCC) samples. PMID: 28731203
3. our results describe for the first time the role of miR-494-3p during normal hematopoietic stem/progenitor cells differentiation and suggest that its increased expression, and the subsequent downregulation of its target SOCS6, might contribute to the megakaryocyte hyperplasia commonly observed in primary myelofibrosis patients. PMID: 28423484
4. miR-142-3p regulates NPC development by down-regulating SOCS6 expression and suggest that modulation of miR-142-3p expression could be a therapeutic strategy for NPC PMID: 26183850
5. Studied both the function of upregulated miR-424-5p in pancreatic cancer and how downstream suppressor of cytokine-induced signaling 6 (SOCS6) is negatively regulated by miR-424-5p. PMID: 23653113
6. miR-17-5p might function as a pro-proliferative factor by repressing SOCS6 in gastric cancer PMID: 24801601
7. Results show that SOCS6 forms complex with DRP1 and the mitochondrial phosphatase PGAM5, attenuates DRP1 phosphorylation, and promotes DRP1 mitochondrial translocation. PMID: 22955947
8. SOCS6 negatively regulates Flt3 activation, the downstream Erk signaling pathway, and cell proliferation. PMID: 22952242
9. Reduced copy number and mRNA expression of SOCS6 are associated with disease recurrence in primary lung squamous cell carcinoma and may be useful prognostic biomarkers. PMID: 22363434
10. The results may contribute to understanding SOCS5 and SOCS6 expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer. PMID: 22081311
11. SOCS6 has ubiquitin ligase activity toward c-KIT PMID: 21030588
12. These results establish that SOCS-6 acts as a negative regulator of T cell activation by promoting ubiquitin-dependent proteolysis of p56(lck). PMID: 20007709
13. Data support the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis. PMID: 19646809
14. HOIL-1 expression stabilizes SOCS6 and induces the ubiquitination and degradation of proteins associated with SOCS6 PMID: 16643902
15. These observations suggest that Erk activation may be correlated in the cells with high expression of SOCS6. PMID: 17210122
16. These observations suggest that SOCS6 is composed of at least two functional domains required for its biological role in localizing and degrading Stat3 in the nucleus. PMID: 17603019
17. Study demonstrated that hypermethylation of the SOCS6 promoter is one of the mechanisms for the epigenetic regulation of SOCS6 expression. PMID: 19716864

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HGNC: 16833

OMIM: 605118

KEGG: hsa:9306

STRING: 9606.ENSP00000381034

UniGene: Hs.44439