SORBS3 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA022406LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SORBS3 Polyclonal antibody

Uniprot No.

O60504

Target Names

SORBS3

Alternative Names

SORBS3 antibody; SCAM1 antibody; Vinexin antibody; SH3-containing adapter molecule 1 antibody; SCAM-1 antibody; Sorbin and SH3 domain-containing protein 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Vinexin protein (1-329AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.

Gene References into Functions

Vinexin beta deficiency attenuates atherogenesis primarily by suppressing vascular inflammation and inactivating Akt-nuclear factor kappaB signaling. Our data suggest that vinexin beta could be a therapeutic target for the treatment of atherosclerosis. PMID: 28209562
The chromosome 8p tumor suppressor genes SORBS3 and SH2D4A are physically and functionally linked and provide a molecular mechanism of inhibiting STAT3-mediated IL-6 signaling in hepatocellular carcinoma cells. PMID: 27311882
Study identified possible epigenetic influence on differential gene expression in SORBS3 under obese conditions. PMID: 27437034
Our findings revealed that Vinexin-beta acts as a novel modulator of ischaemic injury PMID: 25824575
Taken together, the findings suggest that vinexin beta modulates NS5A phosphorylation via its interaction with NS5A, thereby regulating hepatitis C virus replication, implicating vinexin beta in the viral life cycle. PMID: 25972535
Vinexin knockdown using siRNA delayed migration of both HaCaT human keratinocytes and A431 epidermoid carcinoma cells in scratch assay but did not affect cell proliferation. PMID: 20361963
regulates cytoskeletal organization and signal transduction--review PMID: 12510380
vinexin is a novel substrate of ERK2 and may play roles in ERK-dependent cell regulation PMID: 15184391
phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta PMID: 15734736
These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl. PMID: 16923119
Vinexin is enriched at the leading edge of migrating cells, lamellipodia and and focal adhesions in well-spread cells. PMID: 17486060
Rhotekin forms a complex with vinexin and may play a role at focal adhesions. PMID: 19294487

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Subcellular Location

[Isoform Alpha]: Cell junction. Cytoplasm, cytoskeleton.; [Isoform Beta]: Cell junction. Nucleus. Cytoplasm, cytoskeleton.

Tissue Specificity

Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.

Database Links

HGNC: 30907

OMIM: 610795

KEGG: hsa:10174

STRING: 9606.ENSP00000240123

UniGene: Hs.528572

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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