SORBS3 Antibody

Code CSB-PA022406LA01HU
Size US$166
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  • Western blot
    All lanes: SORBS3 antibody at 8µg/ml + HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 76, 37 kDa
    Observed band size: 76 kDa

  • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA022406LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA022406LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SORBS3 Polyclonal antibody
Uniprot No.
Target Names
SORBS3
Alternative Names
SORBS3 antibody; SCAM1 antibody; Vinexin antibody; SH3-containing adapter molecule 1 antibody; SCAM-1 antibody; Sorbin and SH3 domain-containing protein 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Vinexin protein (1-329AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SORBS3 Antibody (Product code: CSB-PA022406LA01HU) is Non-conjugated. For SORBS3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA022406LB01HU SORBS3 Antibody, HRP conjugated ELISA
FITC CSB-PA022406LC01HU SORBS3 Antibody, FITC conjugated
Biotin CSB-PA022406LD01HU SORBS3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
Gene References into Functions
  1. Vinexin beta deficiency attenuates atherogenesis primarily by suppressing vascular inflammation and inactivating Akt-nuclear factor kappaB signaling. Our data suggest that vinexin beta could be a therapeutic target for the treatment of atherosclerosis. PMID: 28209562
  2. The chromosome 8p tumor suppressor genes SORBS3 and SH2D4A are physically and functionally linked and provide a molecular mechanism of inhibiting STAT3-mediated IL-6 signaling in hepatocellular carcinoma cells. PMID: 27311882
  3. Study identified possible epigenetic influence on differential gene expression in SORBS3 under obese conditions. PMID: 27437034
  4. Our findings revealed that Vinexin-beta acts as a novel modulator of ischaemic injury PMID: 25824575
  5. Taken together, the findings suggest that vinexin beta modulates NS5A phosphorylation via its interaction with NS5A, thereby regulating hepatitis C virus replication, implicating vinexin beta in the viral life cycle. PMID: 25972535
  6. Vinexin knockdown using siRNA delayed migration of both HaCaT human keratinocytes and A431 epidermoid carcinoma cells in scratch assay but did not affect cell proliferation. PMID: 20361963
  7. regulates cytoskeletal organization and signal transduction--review PMID: 12510380
  8. vinexin is a novel substrate of ERK2 and may play roles in ERK-dependent cell regulation PMID: 15184391
  9. phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta PMID: 15734736
  10. These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl. PMID: 16923119
  11. Vinexin is enriched at the leading edge of migrating cells, lamellipodia and and focal adhesions in well-spread cells. PMID: 17486060
  12. Rhotekin forms a complex with vinexin and may play a role at focal adhesions. PMID: 19294487

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Subcellular Location
[Isoform Alpha]: Cell junction. Cytoplasm, cytoskeleton.; [Isoform Beta]: Cell junction. Nucleus. Cytoplasm, cytoskeleton.
Tissue Specificity
Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.
Database Links

HGNC: 30907

OMIM: 610795

KEGG: hsa:10174

STRING: 9606.ENSP00000240123

UniGene: Hs.528572

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