SORCS1 Antibody

Datasheet

Code	CSB-PA848843LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: K562 whole cell lysate All lanes: SORCS1 antibody at 3μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 130, 134, 132 kDa Observed band size: 130 kDa Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA848843LA01HU at dilution of 1:100 Immunofluorescence staining of MCF-7 cells with CSB-PA848843LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SORCS1 Polyclonal antibody

Uniprot No.

Q8WY21

Target Names

SORCS1

Alternative Names

SORCS1 antibody; SORCS antibody; VPS10 domain-containing receptor SorCS1 antibody; hSorCS antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human VPS10 domain-containing receptor SorCS1 protein (34-175AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SORCS1 Antibody (Product code: CSB-PA848843LA01HU) is Non-conjugated. For SORCS1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA848843LB01HU	SORCS1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA848843LC01HU	SORCS1 Antibody, FITC conjugated
Biotin	CSB-PA848843LD01HU	SORCS1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Gene References into Functions

We report for the first time the relevance of SORCS1 polymorphisms for glycemic control and glucose stimulated insulin secretion in obese women with polycystic ovary syndrome. SORCS1 rs1416406 significantly influenced stimulated glucose plasma levels and increased glucose stimulated insulin secretion PMID: 27052493
Data identified associations between single nucleotide polymorphisms in SORCS1 and renal function in large cohorts of European and African ancestry. PMID: 23780848
The propeptide region of sorCS1 contains two separate sites for binding to sortilin. One of these sites is removed from human sorCS1 during processing. PMID: 24128306
Genetic variation of the rs10884402 and rs950809 in intron 1 of SORCS1 is associated with late onset Alzheimer disease in the Chinese Han population. PMID: 23700427
The genetic link between AD[Alzheimer's disease]and SORCS1 gene variations are influenced by ethnic background, sex and whether an individual has type 2 diabetes mellitus PMID: 23279143
[review] Emerging data from a rapidly growing area of research implicates the Vps10 family of receptors and the retromer in physiological intracellular trafficking by neurotrophins and pathogenesis of neurodegeneration. PMID: 23055476
Our data suggested that SORCS1 was in interaction with APOE in the development of late-onset Alzheimer's disease in a Northern Han Chinese population PMID: 22353753
suggest that genetic variation in SORCS1 is associated with memory performance PMID: 22046233
Dysfunction of SorCS1 may contribute to both the amyloid precursor protein/amyloidbeta disturbance underlying Alzheimer disease and the insulin/glucose disturbance underlying diabetes mellitus. PMID: 20881129
SNP which is nearest to SORCS1 is highly significantly associated with glycemic control in individuals with type 1 diabetes PMID: 19875614
human sorCS1 has three isoforms, sorCS1a-c, with completely different cytoplasmic tails and differential expression in tissues PMID: 12482870
Different motifs regulate trafficking of SorCS1 isoforms. PMID: 18315530
SORCS1 SNPs show genotypic association with Alzheimer disease. PMID: 19241460

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

VPS10-related sortilin family, SORCS subfamily

Tissue Specificity

Detected in fetal and infant brain and in fetal retina.

Database Links

HGNC: 16697

OMIM: 606283

KEGG: hsa:114815

STRING: 9606.ENSP00000345964

UniGene: Hs.591915

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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