SOX8 Antibody, Biotin conjugated

Code CSB-PA022436LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SOX8 Polyclonal antibody
Uniprot No.
Target Names
SOX8
Alternative Names
MGC24837 antibody; SOX 8 antibody; Sox8 antibody; SOX8_HUMAN antibody; SRY (sex determining region Y) box 8 antibody; SRY box 8 antibody; SRY box containing gene 8 antibody; Transcription factor SOX 8 antibody; Transcription factor SOX-8 antibody; Transcription factor SOX8 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcription factor SOX-8 protein (292-386AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.
Gene References into Functions
  1. SOX8 bounds to the promoter region of FZD7 and induces the FZD7-mediated activation of the Wnt/beta-catenin pathway and confers chemoresistance and stemness properties and mediates epithelial mesenchymal transition in chemoresistant tongue squamous cell carcinoma. PMID: 29071717
  2. Suggest that miRNA-124 may regulate non-small cell lung carcinoma cell proliferation via decreasing SOX8. PMID: 25400731
  3. SOX8 mRNA levels decrease during in vitro dedifferentiation of human articular chondrocytes and increase during chondrogenic differentiation of mesenchymal stromal cells. PMID: 24449344
  4. SOX8 promotes cancer cell proliferation and its expression is correlated with elevated beta-catenin levels in hepatocellular carcinoma PMID: 24643625
  5. The SOX8 single nucleotide polymorphism, rs2744148, is associated with increased genetic risk for multiple sclerosis. PMID: 23739915
  6. Quantitative changes of enteric glia represented by SOX8 provide a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut. PMID: 18512230
  7. SOX2 and SOX17 expression patterns can distinguish between seminoma and embryonal carcinoma, and this distinction may be diagnostically useful. PMID: 19369635

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Subcellular Location
Nucleus.
Database Links

HGNC: 11203

OMIM: 605923

KEGG: hsa:30812

STRING: 9606.ENSP00000293894

UniGene: Hs.243678

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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