SOX8 Antibody

Datasheet

Code	CSB-PA022436LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: U87 whole cell lysate All lanes: SOX8 antibody at 5µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 48 kDa Observed band size: 48 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SOX8 Polyclonal antibody

Uniprot No.

P57073

Target Names

SOX8

Alternative Names

MGC24837 antibody; SOX 8 antibody; Sox8 antibody; SOX8_HUMAN antibody; SRY (sex determining region Y) box 8 antibody; SRY box 8 antibody; SRY box containing gene 8 antibody; Transcription factor SOX 8 antibody; Transcription factor SOX-8 antibody; Transcription factor SOX8 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Transcription factor SOX-8 protein (292-386AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SOX8 Antibody (Product code: CSB-PA022436LA01HU) is Non-conjugated. For SOX8 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA022436LB01HU	SOX8 Antibody, HRP conjugated	ELISA
FITC	CSB-PA022436LC01HU	SOX8 Antibody, FITC conjugated
Biotin	CSB-PA022436LD01HU	SOX8 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.

Gene References into Functions

SOX8 bounds to the promoter region of FZD7 and induces the FZD7-mediated activation of the Wnt/beta-catenin pathway and confers chemoresistance and stemness properties and mediates epithelial mesenchymal transition in chemoresistant tongue squamous cell carcinoma. PMID: 29071717
Suggest that miRNA-124 may regulate non-small cell lung carcinoma cell proliferation via decreasing SOX8. PMID: 25400731
SOX8 mRNA levels decrease during in vitro dedifferentiation of human articular chondrocytes and increase during chondrogenic differentiation of mesenchymal stromal cells. PMID: 24449344
SOX8 promotes cancer cell proliferation and its expression is correlated with elevated beta-catenin levels in hepatocellular carcinoma PMID: 24643625
The SOX8 single nucleotide polymorphism, rs2744148, is associated with increased genetic risk for multiple sclerosis. PMID: 23739915
Quantitative changes of enteric glia represented by SOX8 provide a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut. PMID: 18512230
SOX2 and SOX17 expression patterns can distinguish between seminoma and embryonal carcinoma, and this distinction may be diagnostically useful. PMID: 19369635

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Subcellular Location

Nucleus.

Database Links

HGNC: 11203

OMIM: 605923

KEGG: hsa:30812

STRING: 9606.ENSP00000293894

UniGene: Hs.243678

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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