The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA268589(SPARCL1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA268589(SPARCL1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
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SC1 levels were independently associated with ischemic stroke severity evaluated by the NIHSS. PMID: 29102542
The results of this study suggest that the SPARCL1 accelerates Alzheimer's Disease pathogenesis and thus link neuroinflammation with widespread changes in brain structure and function during aging. PMID: 29154276
The present study demonstrated that the expression of SPARCL1 was downregulated in renal cell carcinoma (RCC) cells and tissues, however, the overexpression of SPARCL1 inhibited RCC cell migration and invasion. PMID: 28944877
This study demonstrated the SPARCL1-containing neurons in the human brainstem and sensory ganglion. PMID: 27357901
tumor endothelial cells heterogeneity is regulated by SPARCL1, which promotes the cell quiescence and vessel homeostasis contributing to the favorable prognoses associated with Th1-tumor microenvironments colorectal carcinomas. PMID: 27721236
SPARCL1 is involved in the tumorigenesis of hilar cholangiocarcinoma and may serve as a novel molecular biomarker for patients' outcome. PMID: 26490986
Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression PMID: 26294211
SPARCL1 expression did not inhibit tumor cell proliferation in vitro. By contrast, SPARCL1 did suppress tumor cell migration and invasiveness in vitro and tumor metastatic growth in vivo, conferring improved survival in xenograft mouse models PMID: 23916135
radiotherapy causes an increase in SPARCL1 expression; SPARCL1 may have a role in survival in rectal cancer patients PMID: 24661672
SPARCL1 functions as a tumor suppressor promoting differentiation possibly via MET, which inhibits the aggressiveness of colorectal cancers PMID: 22891198
Sparc-like protein 1 expression correlates with glioma grade, suggesting the possible role for this protein in the progression of this malignancy. PMID: 22909274
SPARCL1 is a potent regulator of cell migration/invasion and its loss is independently associated with prostate cancer recurrence. PMID: 22927397
Data suggest that the expression of SPARCL1 protein might be a valuable biomarker for early diagnosis in colorectal cancers and further predicting patients' prognosis. PMID: 21887554
Down-regulated SPARCL1 is associated with gastric cancer. PMID: 22161898
Data suggest that SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are potential prognostic markers in colorectal cancer. PMID: 21528083
Overall, these results suggested that the C-t of hevin contains important determinants for interaction with myocilin. PMID: 16316624
hevin can modulate the structure of dermal extracellular matrix, specifically by its regulation of decorin levels and collagen fibril assembly PMID: 16844696
Despite proteomic studies in CSF from MS patients suggested an important role for SPARCL1 in the development of the disease, SPARCL1 gene does not appear to act as susceptibility factor for MS in the population investigated here. PMID: 17825989
A transgenic mouse model in which SPARCL1 is expressed in radial glia provides a novel in vivo system for evaluating the role of SPARCL1 in brain development and function. PMID: 18381651
Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.