SPC24 Antibody

Code CSB-PA836712LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA836712LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SPC24 Polyclonal antibody
Uniprot No.
Target Names
SPC24
Alternative Names
FLJ90806 antibody; hSpc24 antibody; Kinetochore protein Spc24 antibody; SPBC24 antibody; spc24 antibody; SPC24 NDC80 kinetochore complex component antibody; SPC24 NDC80 kinetochore complex component homolog antibody; SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) antibody; SPC24_HUMAN antibody; Spindle pole body component 24 homolog (S. cerevisiae) antibody; Spindle pole body component 24 homolog antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Kinetochore protein Spc24 protein (21-97AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SPC24 Antibody (Product code: CSB-PA836712LA01HU) is Non-conjugated. For SPC24 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA836712LB01HU SPC24 Antibody, HRP conjugated ELISA
FITC CSB-PA836712LC01HU SPC24 Antibody, FITC conjugated
Biotin CSB-PA836712LD01HU SPC24 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Gene References into Functions
  1. SPC24 is up-regulated in human breast cancer.SPC24 regulates PI3K/AKT kinase pathway in breast cancer. PMID: 30180968
  2. our data demonstrates that SPC24 can serve as a promising prognostic biomarker of anaplastic thyroid cancer cells PMID: 28423533
  3. Data indicate that kinetochore protein Spc24 (SPC24) may be a promising molecular target for hepatocellular carcinoma (HCC) therapy. PMID: 26515591
  4. hSPC24 is a component of the human NDC80 kinetochore complex PMID: 14699129
Subcellular Location
Nucleus. Chromosome, centromere, kinetochore.
Protein Families
SPC24 family
Database Links

HGNC: 26913

OMIM: 609394

KEGG: hsa:147841

STRING: 9606.ENSP00000465075

UniGene: Hs.381225

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