SPG21 Antibody

Datasheet

Code	CSB-PA889158LA01HU
Size	US$166
	Order now
Image	Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA889158LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA889158LA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA889158LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The Latest Promotion
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SPG21 Polyclonal antibody

Uniprot No.

Q9NZD8

Target Names

SPG21

Alternative Names

SPG21 antibody; ACP33 antibody; BM-019 antibody; GL010 antibody; Maspardin antibody; Acid cluster protein 33 antibody; Spastic paraplegia 21 autosomal recessive Mast syndrome protein antibody; Spastic paraplegia 21 protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Maspardin protein (1-308AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SPG21 Antibody (Product code: CSB-PA889158LA01HU) is Non-conjugated. For SPG21 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA889158LB01HU	SPG21 Antibody, HRP conjugated	ELISA
FITC	CSB-PA889158LC01HU	SPG21 Antibody, FITC conjugated
Biotin	CSB-PA889158LD01HU	SPG21 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

May play a role as a negative regulatory factor in CD4-dependent T-cell activation.

Gene References into Functions

HBV X gene enhanced SPG21 gene promoter activity, SPG21 mRNA expression and SPG21 protein production in HepG2 cells in a dose-dependent manner. PMID: 21205478
frameshift results in the premature termination of the encoded product, which is designated "maspardin" (Mast syndrome, spastic paraplegia, autosomal recessive with dementia) PMID: 14564668
Data report that maspardin localizes prominently to cytoplasm as well as to membranes, possibly at trans-Golgi network/late endosomal compartments, and that maspardin interacts with the aldehyde dehydrogenase ALDH16A1. PMID: 19184135

Involvement in disease

Spastic paraplegia 21, autosomal recessive (SPG21)

Subcellular Location

Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans-Golgi network.

Protein Families

AB hydrolase superfamily

Tissue Specificity

Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level).

Database Links

HGNC: 20373

OMIM: 248900

KEGG: hsa:51324

STRING: 9606.ENSP00000204566

UniGene: Hs.242458

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Endocytosis

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Place an order now

I. Product details

Product name *

Code *

Size *

Quantity *

Message

II. Contact details

Name *

Email address *

Company/Organization

Phone

III. Ship To

Address *

City *

State/Province *

Zip/Post code *

Country *

Attn Name *

Phone# *

IV. Bill To Same as Shipping Address