SPINK9 Antibody

Datasheet

Code	CSB-PA707717LA01HU
Size	US$166
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Image	IHC image of CSB-PA707717LA01HU diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SPINK9 Polyclonal antibody

Uniprot No.

Q5DT21

Target Names

SPINK9

Alternative Names

SPINK9 antibody; LEKTI2Serine protease inhibitor Kazal-type 9 antibody; Lymphoepithelial Kazal-type-related inhibitor 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Serine protease inhibitor Kazal-type 9 protein (20-86AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SPINK9 Antibody (Product code: CSB-PA707717LA01HU) is Non-conjugated. For SPINK9 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA707717LB01HU	SPINK9 Antibody, HRP conjugated	ELISA
FITC	CSB-PA707717LC01HU	SPINK9 Antibody, FITC conjugated
Biotin	CSB-PA707717LD01HU	SPINK9 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.

Gene References into Functions

SPINK9 has a role in stimulating metalloprotease/EGFR-dependent keratinocyte migration by purinergic receptor pathway activation PMID: 24441102
the inhibition and binding of different SPINK9 variants towards KLK5, KLK7, KLK8 and KLK14 PMID: 22505519
mSPINK12 shows an inhibitory activity against murine keratinocyte-derived trypsin-like proteolytic activity, and thus, appears orthologous to human LEKTI2 and may play an role in the regulation of epithelial cell functions. PMID: 21899598
A new KLK5-inhibiting peptide encoded by a member of the Spink family, designated as Spink9 located on chromosome 5p33.1, was identified. PMID: 19190773
possible role for SPINK9 in the site-specific epidermal differentiation of palms and soles PMID: 19194479

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Subcellular Location

Secreted.

Tissue Specificity

Skin. Highly expressed at sites of hyperkeratosis. Also detected in thymus, tonsils, testis, pancreas, liver, placenta and brain. Expressed at stratum granulosum and stratum corneum at palmar and plantar sites (at protein level).

Database Links

HGNC: 32951

OMIM: 613511

KEGG: hsa:643394

STRING: 9606.ENSP00000367139

UniGene: Hs.631798

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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