SPINK9 Antibody, FITC conjugated

Code CSB-PA707717LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SPINK9 Polyclonal antibody
Uniprot No.
Target Names
SPINK9
Alternative Names
SPINK9 antibody; LEKTI2Serine protease inhibitor Kazal-type 9 antibody; Lymphoepithelial Kazal-type-related inhibitor 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Serine protease inhibitor Kazal-type 9 protein (20-86AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.
Gene References into Functions
  1. SPINK9 has a role in stimulating metalloprotease/EGFR-dependent keratinocyte migration by purinergic receptor pathway activation PMID: 24441102
  2. the inhibition and binding of different SPINK9 variants towards KLK5, KLK7, KLK8 and KLK14 PMID: 22505519
  3. mSPINK12 shows an inhibitory activity against murine keratinocyte-derived trypsin-like proteolytic activity, and thus, appears orthologous to human LEKTI2 and may play an role in the regulation of epithelial cell functions. PMID: 21899598
  4. A new KLK5-inhibiting peptide encoded by a member of the Spink family, designated as Spink9 located on chromosome 5p33.1, was identified. PMID: 19190773
  5. possible role for SPINK9 in the site-specific epidermal differentiation of palms and soles PMID: 19194479

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Subcellular Location
Secreted.
Tissue Specificity
Skin. Highly expressed at sites of hyperkeratosis. Also detected in thymus, tonsils, testis, pancreas, liver, placenta and brain. Expressed at stratum granulosum and stratum corneum at palmar and plantar sites (at protein level).
Database Links

HGNC: 32951

OMIM: 613511

KEGG: hsa:643394

STRING: 9606.ENSP00000367139

UniGene: Hs.631798

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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