SPO11 Antibody, FITC conjugated

Code CSB-PA897506LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SPO11 Polyclonal antibody
Uniprot No.
Target Names
SPO11
Alternative Names
Cancer/testis antigen 35 antibody; CT35 antibody; Meiotic recombination protein SPO 11 antibody; Meiotic recombination protein SPO11 antibody; MGC39953 antibody; SPATA43 antibody; Spermatogenesis associated 43 antibody; SPO 11 antibody; SPO11 antibody; SPO11 meiotic protein covalently bound to DSB antibody; SPO11 meiotic protein covalently bound to DSB homolog antibody; SPO11 meiotic protein covalently bound to DSB like antibody; SPO11_HUMAN antibody; TOPVIA antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Meiotic recombination protein SPO11 protein (28-109AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
Gene References into Functions
  1. SPO11 gene C631T polymorphism may contribute as a genetic factor susceptible to cause male infertility in Chinese. PMID: 28050928
  2. Data suggest that the combined genotypes of glutathionine S-transferase GSTM1 (-/-), GSTT1 (+/+), GSTP1 (AA) and meiotic recombination protein SPO11 (CT) may be associated with idiopathic male infertility in ethnic Han Chinese. PMID: 26663067
  3. Polymorphisms within the SPO11 gene are linked to the susceptibility of azoospermia and oligozoospermia male infertility. PMID: 25005169
  4. SPO11 might has an effect on premorbid functioning, which increase susceptibility for idiopathic male reproduction PMID: 21556891
  5. Mutations in the human SPO11 gene are not common causes of infertility in man PMID: 16169419
  6. Data show that there is no association between SPO11 gene mutation and premature ovarian failure. PMID: 18166824

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Subcellular Location
Nucleus.
Protein Families
TOP6A family
Tissue Specificity
Highly expressed in testis.
Database Links

HGNC: 11250

OMIM: 605114

KEGG: hsa:23626

STRING: 9606.ENSP00000360310

UniGene: Hs.159737

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