SPO11 Antibody

Datasheet

Code	CSB-PA897506LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Jurkat whole cell lysate, Raji whole cell lysate, HepG2 whole cell lysate, 293T whole cell lysate All lanes: SPO11 antibody at 5.8µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 45, 41 kDa Observed band size: 45 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SPO11 Polyclonal antibody

Uniprot No.

Q9Y5K1

Target Names

SPO11

Alternative Names

Cancer/testis antigen 35 antibody; CT35 antibody; Meiotic recombination protein SPO 11 antibody; Meiotic recombination protein SPO11 antibody; MGC39953 antibody; SPATA43 antibody; Spermatogenesis associated 43 antibody; SPO 11 antibody; SPO11 antibody; SPO11 meiotic protein covalently bound to DSB antibody; SPO11 meiotic protein covalently bound to DSB homolog antibody; SPO11 meiotic protein covalently bound to DSB like antibody; SPO11_HUMAN antibody; TOPVIA antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Meiotic recombination protein SPO11 protein (28-109AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SPO11 Antibody (Product code: CSB-PA897506LA01HU) is Non-conjugated. For SPO11 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA897506LB01HU	SPO11 Antibody, HRP conjugated	ELISA
FITC	CSB-PA897506LC01HU	SPO11 Antibody, FITC conjugated
Biotin	CSB-PA897506LD01HU	SPO11 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.

Gene References into Functions

SPO11 gene C631T polymorphism may contribute as a genetic factor susceptible to cause male infertility in Chinese. PMID: 28050928
Data suggest that the combined genotypes of glutathionine S-transferase GSTM1 (-/-), GSTT1 (+/+), GSTP1 (AA) and meiotic recombination protein SPO11 (CT) may be associated with idiopathic male infertility in ethnic Han Chinese. PMID: 26663067
Polymorphisms within the SPO11 gene are linked to the susceptibility of azoospermia and oligozoospermia male infertility. PMID: 25005169
SPO11 might has an effect on premorbid functioning, which increase susceptibility for idiopathic male reproduction PMID: 21556891
Mutations in the human SPO11 gene are not common causes of infertility in man PMID: 16169419
Data show that there is no association between SPO11 gene mutation and premature ovarian failure. PMID: 18166824

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Subcellular Location

Nucleus.

Protein Families

TOP6A family

Tissue Specificity

Highly expressed in testis.

Database Links

HGNC: 11250

OMIM: 605114

KEGG: hsa:23626

STRING: 9606.ENSP00000360310

UniGene: Hs.159737

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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