SPRR2A Antibody, Biotin conjugated

Code CSB-PA842658LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SPRR2A Polyclonal antibody
Uniprot No.
Target Names
SPRR2A
Alternative Names
2 1 antibody; 2-1 antibody; Small proline rich protein 2A antibody; Small proline-rich protein 2A antibody; SPR 2A antibody; SPR-2A antibody; SPR2A_HUMAN antibody; SPRR2A antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Small proline-rich protein 2A protein (1-72AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Gene References into Functions
  1. SPRR2a modulates ZEB-1 signaling by way of miR-200c/141-associated epithelial mesenchyme transition through SH3-domain networks and contributes to benign and malignant wound-healing responses. PMID: 24123265
  2. SPRR2A-associated tumor behavior was mimicked by MUC1 shRNA, which induced EMT and, like SPRR2A+ cells, showed reduced metastatic capabilities PMID: 23728799
  3. SPRR2A functions as a suppressor of p53-dependent transcriptional activity, which otherwise might impede cellular processes needed for epithelial wound repair responses. PMID: 22731250
  4. Small proline-rich proteins (SPRR2A) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes. PMID: 18155796
Subcellular Location
Cytoplasm.
Protein Families
Cornifin (SPRR) family
Database Links

HGNC: 11261

OMIM: 182267

KEGG: hsa:6700

STRING: 9606.ENSP00000376423

UniGene: Hs.355542

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