SPRR2A is an essential protein belonging to the SPRR (small proline-rich protein) family, genetically located at 1q21.3. It constitutes a component of the keratinocyte envelope, providing a protective barrier function to stratified squamous epithelial cells. SPRR2A features a short N-terminal domain followed by three repeating SPRR2 consensus sequences of PKCPEPCPP and a long C-terminal tail domain. SPRR2A promotes intestinal innate immunity by shaping the composition of the gut microbiota and limiting pathogenic infections caused by Gram-positive bacteria. Its role is particularly prominent during intestinal worm infections, where type 2 cytokines produced during worm infection selectively increase the expression of SPRR2A, protecting the intestinal barrier and preventing bacterial invasion and dissemination triggered by worm infections. Furthermore, SPRR2A differs from previously characterized proline-rich AMPs (antimicrobial peptides) by disrupting bacterial membranes and selectively targeting Gram-positive bacteria. Research has found that during intestinal bacterial infections, the expression of SPRR2A protein is significantly upregulated through the activation of the TLR-MyD88 signaling pathway, revealing the molecular mechanism of SPRR2A's response to bacterial infections.
Recombinant Mouse Small proline-rich protein 2A1 (Sprr2a1)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The following SPRR2A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SPRR2A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA842658LA01HU | SPRR2A Antibody |
Human | ELISA |
CSB-PA842658LC01HU | SPRR2A Antibody, FITC conjugated |
Human | |
CSB-PA842658LD01HU | SPRR2A Antibody, Biotin conjugated |
Human | ELISA |
SPRR2A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP022612HU CSB-EP022612HU CSB-BP022612HU CSB-MP022612HU CSB-EP022612HU-B |
Recombinant Human Small proline-rich protein 2A (SPRR2A) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |