SRCIN1 Antibody

1. SRCIN1 functions to inhibit the proliferation and EMT of human liver cancer HepG2 cells. PMID: 28550679
2. Data indicate that the major mechanism is the ability of p140Cap to interfere with ERBB2-dependent activation of Rac GTPase-controlled circuitries. PMID: 28300085
3. Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex. PMID: 28641114
4. SRCIN1 underexpression is associated with Osteosarcoma. PMID: 27513473
5. Together, these results demonstrate that Srcin1 contributes to CRC carcinogenesis, invasion and metastasis. These findings provide a rationale for a mechanistic approach to CRC treatment based on the development of Srcin1-targeted therapies PMID: 28393242
6. miR-211 may function as an oncogenic miRNA in non-small cell lung cancer, partly by regulating SRCIN1 PMID: 26277787
7. miR-346 may function as an oncogenic miRNA and mediate chemosensitivity to docetaxel through targeting SRCIN1 in breast cancer PMID: 27913185
8. these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap PMID: 25771685
9. these findings suggest that miR-374a functions as a candidate oncogene in GC by directly targeting SRCIN1 PMID: 25554419
10. Findings indicate the role of miR-150 as an oncogene in lung cancer through the inhibition of SRC kinase signalling inhibitor 1 (SRCIN1) translation. PMID: 24456795
11. p140Cap phosphorylation sites and binding to Csk and Abl kinase PMID: 23383002
12. p140Cap immobilizes E-cadherin at the cell membrane and inhibits EGFR and Erk1/2 signalling, blocking scatter and proliferation of cancer cells. PMID: 20453886
13. provides the first evidence that p140Cap is a novel negative regulator of tumour growth PMID: 17525734
14. Expression correlated significantly with unfavourable overall survival, suggesting that SNIP/p140Cap may be a useful diagnostic and prognostic marker, aas well as therapeutic target, in breast cancer. PMID: 18475297

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HGNC: 29506

OMIM: 610786

KEGG: hsa:80725

STRING: 9606.ENSP00000264659

UniGene: Hs.448872