SRSF9 Antibody

Datasheet

Citations (1)

Code	CSB-PA00214A0Rb
Size	US$166
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Image	Western blot All lanes: SRSF9 antibody at 2µg/ml + Mouse kidney tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 26 kDa Observed band size: 26 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SRSF9 Polyclonal antibody

Uniprot No.

Q13242

Target Names

SRSF9

Alternative Names

arginine/serine-rich 9 antibody; Pre mRNA splicing factor SRp30C antibody; Pre-mRNA-splicing factor SRp30C antibody; Serine/arginine-rich splicing factor 9 antibody; SFRS 9 antibody; Splicing factor antibody; Splicing factor arginine/serine rich 9 antibody; splicing factor, arginine/serine-rich 9 antibody; splicing factor, arginine/serine-rich, 30-KD, C antibody; SR splicing factor 9 antibody; SRP30C antibody; SRSF9 antibody; SRSF9_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Serine/arginine-rich splicing factor 9 protein (1-221AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SRSF9 Antibody (Product code: CSB-PA00214A0Rb) is Non-conjugated. For SRSF9 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA00214B0Rb	SRSF9 Antibody, HRP conjugated	ELISA
FITC	CSB-PA00214C0Rb	SRSF9 Antibody, FITC conjugated
Biotin	CSB-PA00214D0Rb	SRSF9 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.1mol/L NaCl, 15mmol/L NaN3, PH7.2

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Citations

Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery R Blázquez-Encinas,Journal of Translational Medicine,2023

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Target Background

Function

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.

Gene References into Functions

Dehydroepiandrosterone (DHEA) and cortisol modulate SRSF9 and SRSF3 in a different way and data suggest that the anti-glucocorticoid effect of DHEA, among other mechanisms, is also exerted by modulating the expression of proteins involved in the splicing of the GR pre-mRNA. PMID: 28373129
Report no correlation between expression of glucocorticoid receptor isoforms and SRp30c. PMID: 25665148
Overexpression of SRSF9 and SRSF1 promote beta-catenin accumulation via the recruitment of beta-catenin mRNA and by enhancing its translation in an mTOR-dependent manner. PMID: 23592547
Relative levels of SRp20, SRp30c, and SRp40 in TM cells control differential expression of the two alternatively spliced isoforms of the GR and thereby regulate GC responsiveness. PMID: 22205602
these data indicated that tumor suppressive miR-1 induces apoptosis through direct inhibition of SRSF9 in bladder cancer. PMID: 22178073
These results suggest that SRp30c can activate human papillomavirus type 16 L1 mRNA expression via a bimodal mechanism: directly by stimulating splicing to late splice sites and indirectly by inhibiting competing early splice sites. PMID: 21697349
SRp30c can function as a repressor of 3' splice site utilization and suggest that the SRp30c-CE9 interaction may contribute to the control of hnRNP A1 alternative splicing. PMID: 12024014
SRp30c protein is an interacting protein of YB-1 PMID: 12604611
Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils. PMID: 12738786
Results suggest that bombesin-induced expression of SRp30c affects gllucorticoid receptor (GR) pre-mRNA splicing, leading to increased GR beta expression and contributing to glucocorticoid resistance in PC cells. PMID: 17540466
Study shows that PTB can function as an anti-repressor molecule to counteract the splicing inhibitory activity of SRp30c. PMID: 17548433
SRp30c stimulates splicing to the downstream 5' splice site of Bcl-x(L), thereby attenuating the repressive effect of upstream U1 snRNP binding sit PMID: 18534987
findings indicate the importance of arginine methylation for the subnuclear localization of SFRS9. PMID: 19557313

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Subcellular Location

Nucleus. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells.

Protein Families

Splicing factor SR family

Tissue Specificity

Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle.

Database Links

HGNC: 10791

OMIM: 601943

KEGG: hsa:8683

STRING: 9606.ENSP00000229390

UniGene: Hs.706889

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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