SSH1 Antibody, FITC conjugated

1. SSH1 binds to gelsolin via actin filaments in the cytosolic fraction. Gelsolin promoted solubilization of actin filaments and SSH1 in cell-free assays and in cultured cells. PMID: 25451266
2. the N-terminal PH-like domain plays a critical role in F-actin binding and F-actin-mediated activation of the cofilin-phosphatase activity of SSH1 PMID: 27865840
3. Results reveal that SSH1L is upregulated in a subset of PCs and that the SSH1L/cofilin-1 signal pathway is associated positively in PC with cell migration. PMID: 25684665
4. Authors show that viral penetration-induced calcium release facilitated herpes simplex virus type 1 intracellular trafficking through activating slingshot 1 (SSH), a phosphatase regulating actin filament dynamics. PMID: 24670325
5. The association of IRS4 with SSH1 contributes to localized activation of cofilin in membrane protrusions. PMID: 25100728
6. Slingshot 1 downregulation in neuronal cells inactivates cofilin to facilitate HSV-1 replication. PMID: 24418541
7. Results identify a novel frameshift mutation in this gene implicated in disseminated superficial actinic porokeratosis in 4 Chinese families PMID: 23834120
8. Thus this study provides evidence for a novel role of LIMK1 and SSH-1L in selectively regulating endothelial cell inflammation associated with intravascular coagulation. PMID: 24039253
9. Our work provides evidence that supports the positive role of SSH1L in the mechanism of stem cell differentiation into cardiomyocyte-like cells. PMID: 23247370
10. A high expression of SSH-1L in peripheral eosinophils in acute exacerbations of asthma may play a role in the activation and migration of eosinophils. PMID: 21690039
11. EphA signaling promotes actin-based dendritic spine remodeling through slingshot 1. PMID: 22282498
12. identified Ser 402 as a new phosphorylation site within the catalytic domain of human slingshot 1 (SSH1). PMID: 21525957
13. Results show the significance of SSH1L in estrogen-induced osteoblastogenic differentiation in favor of adipogenic differentiation from hMSCs. PMID: 21289500
14. SSH1 plays a critical role in cytokinesis by dephosphorylating and reactivating cofilin in later stages of mitosis PMID: 12807904
15. findings suggest that SSH1L is activated downstream of PI3K and plays a critical role in insulin-induced membrane protrusion by dephosphorylating and activating cofilin PMID: 14645219
16. SSH1L is locally activated by translocation to and association with F-actin in lamellipodia in response to neuregulin-1beta and 14-3-3 proteins negatively regulate SSH1L activity by sequestering it in the cytoplasm. PMID: 15159416
17. SSH1 mutations seen in patients with disseminated superficial actinic porokeratosis PMID: 15459975
18. a multi-protein complex consisting of SSH-1L, LIMK1, actin, and the scaffolding protein, 14-3-3zeta, is involved, along with the kinase, PAK4, in the regulation of ADF/cofilin activity PMID: 15660133
19. Ca2+-induced cofilin dephosphorylation is mediated by calcineurin-dependent activation of SSH1L PMID: 15671020
20. identified sites that play unique roles in the control of subcellular localization and F-actin-mediated activation of SSH1L PMID: 16513117
21. Expression of phosphatase-dead versions of SSH proteins, SSH1, SSH2 & SSH3 results in phosphorylation/inactivation of cofilin, changes in cytoskeleton organization, loss of cell polarity, and assembly of aberrant arrays of laminin-332 in keratinocytes. PMID: 17848544
22. PDGF participates in actin dynamics by dual regulation of cofilin activity via LIMK and SSH1L in aortic smooth muscle cells PMID: 18096821
23. the conserved SSH-N domain of slingshot-1 plays critical roles in P-cofilin recognition, F-actin-mediated activation, and subcellular localization of SSH1 PMID: 18809681
24. Results suggest that the formation of ROS by NADPH oxidases engages a SSH-1L-cofilin pathway to regulate cytoskeletal organization and cell migration. PMID: 19339277
25. These results implicate 14-3-3zeta/tau heterodimers as key regulators of SSH1 activity in keratinocytes and suggest they play a role in cytoskeleton remodeling during cell migration. PMID: 19371722
26. Data identify PKD as a central regulator of the cofilin signaling network via direct phosphorylation and regulation of SSH1L. PMID: 19567672

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HGNC: 30579

OMIM: 606778

KEGG: hsa:54434

STRING: 9606.ENSP00000315713

UniGene: Hs.199763