ST7 Antibody

1. The tumor suppressor ST7 is a key gene silenced by PRMT5. PMID: 24453002
2. ST7 mediates tumor suppression through the regulation of the genes involved in maintaining the cellular structure of the cell and involved in oncogenic pathways PMID: 20238225
3. Mutational analysis of ST7 in a wide range of cell lines and primary epithelial cancer failed to detect mutations at this locus, with the exception of 1 missense change in a breast cancer cell line. PMID: 12107844
4. The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system PMID: 12213198
5. The ST7 gene is not a primary target of inactivation in most human cancers with loss of heterozygosity at 7q31.1-q31.2. PMID: 12231539
6. These data suggest that LOH at 7q31-q35 is involved in the origin or progression of at least a subset of esophageal carcinomas, but that ST7 is not the target gene of this somatic event. PMID: 12545169
7. somatic mutations of ST7 do not commonly contribute to the molecular pathogenesis of human malignant myeloid tumors PMID: 14534688
8. ST7 gene may not be the target gene of inactivation at 7q31 site in gastric carcinoma. PMID: 14669308

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HGNC: 11351

OMIM: 600833

KEGG: hsa:7982

STRING: 9606.ENSP00000265437

UniGene: Hs.368131